U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1581 - 1590 of 14117 results

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Sericoside Phytosome is a patent complex between Sericoside and soy phospholipids. Terminalia sericea, from which Sericoside was isolated and extracted for the frst time by Indena, has been traditionally used in Africa and Asia for the treatment of severe skin diseases. The adjective sericea, in ancient Latin, means “silky, smooth as silk”. Sericoside Phytosome 0.5% emulsion was applied twice daily for 42 days on all wrinkles called crow's feet, reproducing normal conditions of use. The product showed to be efficacious in over 70% of the tested female subjects, accomplishing a reduction in wrinkles depth and total wrinkled surface. Many trials have been performed and Sericoside has shown to have skin-restructuring, capillary protecting activity, wound healing and anti-oedema properties. This is due to a remarkable reduction of capillary permeability exerted by the active ingredient.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Sclareol isolated from Salvia officinalis is widely used as a fragrance material. Sclareol is known to exert various biological activities. Sclareol possesses high lipophilicity, that precluded the evaluation of its anticancer effect in vivo. To overcome high toxicity and high lipophilicity of clareol, it was incorporated in liposomes. It demonstrated significant cytotoxic activity against human leukemic cell lines, but no cytotoxicity towards normal cells at concentration as high as 100 uM. Thus, sclareol possesses chemotherapeutic potential for the treatment of colorectal and other types of human cancer. Also was found, that sclareol-containing cream improved wrinkles in a clinical trial. It alleviates facial wrinkle formation via an antiphotoaging mechanism and may be an effective candidate ingredient. The anti-inflammatory mechanisms of sclareol might be related to a decrease of inflammatory cytokines and an increase of antioxidant enzyme activity.

Showing 1581 - 1590 of 14117 results