Fallntolol is a beta-adrenergic receptor antagonist. Falintolol does not produce any noteworthy side effects and is capable of being an effective beta-blocking agent in open-angle glaucoma therapy.

Broparestrol, (Z)- is an isomer of Broparestrol -- synthetic, nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that has been used in Europe as a dermatological agent and for the treatment of breast cancer. Broparestrol, (Z)- and Broparestrol, (E)- demonstrates antiestrogenic activity but, unlike broparestrol, were never marketed.

Istaroxime is a novel intravenous agent with luso-inotropic properties that acts by inhibition of Na( )/K( ) adenosine triphosphatase and stimulation of sarco/ endoplasmic reticulum calcium ATPase isoform 2. It is significantly decreased left ventricular end-diastolic pressure, pulmonary capillary wedge pressure, heart rate and increased systolic blood pressure and cardiac index with no change in neurohormones, renal function or troponin I. Istaroxime has successfully concluded phase II clinical trials in cardiac failure patients. Istaroxime induced apoptosis, affected the key proliferative and apoptotic mediators c-Myc and caspase-3 and modified actin cytoskeleton dynamics and RhoA activity in prostate cancer cells – this provides novel insights into the anti-cancer properties of istaroxime further supporting the development of this agent as a novel anti-cancer drug candidate.

Phosphopantothenic acid is an amidoalkyl phosphate that is the 4-phosphate derivative of (R)-pantothenic acid. Phosphopantothenic acid is not permeable to cell membranes due to its anionic character, consistent with the observation that systemic administration of Phosphopantothenic acid does not restore CoA levels in cellular and mouse models

Quindonium is azaestrone derivative patented by Shionogi & Co., Ltd. As an anti-inflammatory agent. Quindonium acts as a bradycardic agent which disrupts regular sinus rhythm in barbiturate-anesthetized dogs. Sinus bradycardias were interrupted by periods of sinus acceleration during which the disturbances in the lead II electrocardiogram were either minor or absent. The rate and rhythm changes were resistant to vagotomy or atropine, propranolol, and pentolinium. Propranolol enhanced the responses and precipitated arrhythmias in resistant animals; carotid sinus denervation had the opposite effect. Prophylactic administration of Quindonium (10 mg/kg) 15 minutes before hemorrhage produced a significant increase in the survival rate of dogs exposed to hemorrhage stress

IPROCINODINE, a semisynthetic antibiotic, is a mixture of the isopropylated cinodine I and cinodide II, glycolipid antibiotics isolated from Nocardia species.

Indium Chloride In-113 is a salt of the only stable Indium isotope with applications in organic synthesis as a Lewis acid. Indium Chloride is the most available soluble derivative of indium with high reproductive toxicity. In in vitro models, Indium Chloride inhibits cell viability by elevating intracellular ROS and inducing apoptosis. In animal models Indium chloride exposure cause the accumulation of indium in blood and lung, bone marrow micronucleus rate increased, the occurrence of oxidative damage and pathological changes. Besides that, the indium chloride exposed showed significant toxicity to sperm function, as well as an increased percentage of sperm morphological abnormality and chromatin DNA damage.

Xanthocillin is an antibiotic derived from Penicillium notatum. In vitro tests have shown that most of the common Gram-positive and Gram-negative pathogens, including Proteus and Pseudomonas pyocyanea, are sensitive to xanthocillin. Xanthocillin participated in the trial in patients with a variety of eczematous and intertriginous eruptions, in all of which bacterial infection was thought to be playing a part. Xanthocillin cream produced results, which were on par with other treatments. Information about the current use of this agent is not available.