U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1481 - 1490 of 2814 results

Acetyl-β-boswellic acid (or 3-O-acetyl-β-BA or AβBA) is a cytotoxic compound, which can be isolated from the gum resins of various Boswellia species. It was studied the mechanism of action of this compound on prostate cancer cells and was revealed, that AβBA inhibits IκB kinase (IKK) activity, leading to subsequent inhibition of the antiapoptotic proteins Bcl-2 and Bcl-xL and also cyclin D1, a crucial regulator of cell proliferation. This mechanism finally promote apoptosis of the androgen-independent prostate cancer cells. In addition was shown, that AβBA directly interacts with the antimicrobial peptide LL-37. This binding resulted in an inhibition of the functionality of LL-37, that might be a relevant mechanism underlying the anti-inflammatory properties of AβBA and suggested this compound as suitable chemical tools or potential agent for intervention with the antimicrobial peptide LL-37 and related disorders
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Riboflavin 5'-acetate (aka riboflavin acetate) is a derivative of riboflavin which has a single acetylation on the ribityl moiety. There is a patent which describes the use of 'riboflavin acetate' in combination with pravastatin to reduce the serum cholesterol of beagles. However, it should be noted that riboflavin tetraacetate is sometimes colloquially referred to as riboflavin acetate.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Other

Class (Stereo):
CHEMICAL (EPIMERIC)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Fluticasone Acetate is an impurity in commercial preparations of Fluticasone propionate, a derivative of Flumethasone.

Showing 1481 - 1490 of 2814 results