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Restrict the search for
alpha-tocopherol acetate
to a specific field?
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Pamapimod (R-1503, Ro4402257) is a potent and selective inhibitor of p38 mitogen-activated protein kinase alpha. The preclinical data support the conclusion that pamapimod has the ability to inhibit the signs and symptoms of rheumatoid arthritis and other autoimmune diseases. Pamapimod was being developed for use in the treatment of rheumatoid arthritis. There is no clear-cut evidence that pamapimod alone or in the presence of methotrexate is efficacious in subjects with rheumatoid arthritis but it does cause adverse effects. It is unlikely that pamapimod will be useful in the treatment of rheumatoid arthritis.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Etisomicin is a semisynthetic aminoglycoside antibiotic.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Class (Stereo):
CHEMICAL (RACEMIC)
Dotefonium is the anticholinergic, spasmolytic agent.
Class (Stereo):
CHEMICAL (RACEMIC)
FLOTRENIZINE, a diarylmethylpiperazine derivative, is an antihistaminic agent.
Status:
Investigational
Source:
NCT02204397: Phase 2 Interventional Completed Type 1 Diabetes Mellitus
(2015)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Class (Stereo):
CHEMICAL (RACEMIC)
Nicoclonate is a nicotinic acid derivative. It is an antilipidemic drug.
Status:
Investigational
Class (Stereo):
CHEMICAL (ABSOLUTE)
Silydianin is a flavonolignan from Silymarin, which is the major constituent of milk thistle extract. Silydianin, an active constituent of Silybium marianum, have inhibitory properties against the P2Y12 receptor and block ADP-induced blood platelet activation. Silydianin has antiinflammatory activity, it regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger. Silydianin non-competitively inhibits the lipoxygenase from soybeans in vitro. It also inhibits the formation of prostaglandins in vitro.
Status:
Investigational
Source:
INN:doxpicomine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Doxpicomine is the hydrochloride salt of l-3[(dimethylamino)-(m-dioxan-5-yl)methyl]pyridine, a derivative of substituted 1,3 dioxanes. Its analgesic effect appears to be mediated centrally through opiate-like receptors. Preclinical animal studies revealed analgesic activity and duration of action of the same order as that of meperidine and codeine when administered subcutaneously and of codeine but of shorter duration when administered orally. The analgesic effects were reversed by naloxone. The drug did not reduce or antagonize the analgesic effect of morphine. Drowsiness is an expected response to effective analgesics. It was the foremost side effect observed but was of short duration and minimal intensity and did not interfere with the postoperative regimen of coughing, deep breathing, and early ambulation. Nausea and vomiting were not reported after doxpicomine.
Class (Stereo):
CHEMICAL (RACEMIC)
FLUMEXADOL is a non-opioid analgesic. Its prodrug OXAFLOZANE was used as an antidepressant in France till 2004.
