| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H20F2N4O4 |
| Molecular Weight | 406.3833 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C(=O)C(OC2=CC=C(F)C=C2F)=CC3=CN=C(NC(CCO)CCO)N=C13
InChI
InChIKey=JYYLVUFNAHSSFE-UHFFFAOYSA-N
InChI=1S/C19H20F2N4O4/c1-25-17-11(10-22-19(24-17)23-13(4-6-26)5-7-27)8-16(18(25)28)29-15-3-2-12(20)9-14(15)21/h2-3,8-10,13,26-27H,4-7H2,1H3,(H,22,23,24)
| Molecular Formula | C19H20F2N4O4 |
| Molecular Weight | 406.3833 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Pamapimod (R-1503, Ro4402257) is a potent and selective inhibitor of p38 mitogen-activated protein kinase alpha. The preclinical data support the conclusion that pamapimod has the ability to inhibit the signs and symptoms of rheumatoid arthritis and other autoimmune diseases. Pamapimod was being developed for use in the treatment of rheumatoid arthritis. There is no clear-cut evidence that pamapimod alone or in the presence of methotrexate is efficacious in subjects with rheumatoid arthritis but it does cause adverse effects. It is unlikely that pamapimod will be useful in the treatment of rheumatoid arthritis.
Originator
Approval Year
Doses
AEs
Sourcing
PubMed
Patents
Sample Use Guides
Rheumatoid arthritis patients receiving stable doses of methotrexate were randomised to one of six dose groups and received 12 weeks of double-blind pamapimod (up to 300 mg once daily) or matching placebo.
Route of Administration:
Oral
