U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1361 - 1370 of 36626 results

Status:
Investigational
Source:
JAN:POTASSIUM GUAIACOLSULFONATE [JAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Potassium 4-Hydroxy-3-methoxybenzenesulfonate Hemihydrate is the hemihydrate of potassium guaiacolsulfonate. Guaiacolsulfonic acid, commonly used in the form of potassium guaiacolsulfonate. Guaiacolsulfonic acid is used as an expectorant for relieving symptoms of cough and mucus in the chest due to respiratory infections, asthma, colds, or hay fever. Guaiacolsulfonate works by thinning mucus (phlegm) in the lungs and making it less sticky and easier to cough up. 'is reduces chest congestion by making coughs more productive.
Status:
Investigational
Source:
INN:sodium picofosfate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Picofosforic acid is the laxative.
Status:
Investigational
Source:
NCT02253342: Phase 1 Interventional Completed Intrapulmonary Pharmacokinetics of WCK 2349
(2014)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Levonadifloxacin is the S-(-) isomer of the benzoquinolizine fluoroquinolone nadifloxacin and is two- to four-fold more active than the racemic mixture. Levonadifloxacin is a potent antibacterial agent against Gram-positive bacteria especially against methicillin resistance Staphylococcus aureus. It also possesses potent bactericidal activity against other resistant variants like quinolone-resistant Staphylococcus aureus, vancomycin and glycopeptide intermediate Staphylococcus aureus and vancomycin resistant Staphylococcus aureus. Intravenous dosage form developed to treat complicated skin and skin structure infections and has recently completed Phase III studies in India and Phase I studies in USA.
Status:
Investigational
Source:
USAN:Asperlin
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Asperlin (also known as U-13,933), a fungal natural product that was isolated from marine-derived fungus Aspergillus sp. SF-5044 and exhibits antifungal and anti-inflammatory properties in vitro. Experiments in vivo have shown that this compound can prevent atherosclerosis through suppressing inflammation rather than ameliorating dyslipidemia. In addition, asperlin can be developed as a potential anti-cancer therapeutics. It shows anti-cancer properties through ROS generation and ATM pathway in human cervical carcinoma cells.
Status:
Investigational
Source:
USAN:LEVALBUTEROL SULFATE [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
USAN:Acetyltannic Acid
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Acetyltannic acid is an astringent (intestinal) for foals, calves, dogs. It is used for treatment of diarrhoea.
Status:
Investigational
Source:
INN:sodium hexacyclonate [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Hexacyclonic Acid (aka gevilon) has been clinically demonstrated to produce hypolipidemic effects. It has been investigated as a treatment for coronary heart disease, and hypertensive disease with severe lipid metabolic disturbances. Gevilon has been found to have a hypolipidemic effect in reducing the levels of total cholesterol, beta-cholesterol, triglycerides, increasing alpha-cholesterol levels and normalizing the atherogenicity coefficient; especially in patients with Type IIb dyslipoproteinemia.
Status:
Investigational
Source:
NCT01327027: Phase 1 Interventional Completed Healthy
(2011)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:ganglefene [INN]
Source URL:

Class (Stereo):
CHEMICAL (UNKNOWN)

Ganglefene is a coronary vasodilator. This n-cholinoblocker was originally studied for its effects on coronary circulation in angina pectoris. Animal studies have also shown shortened recovery period of motor functions after ganglefene administration. One rodent study showed that modulation of the n-cholinergic system by ganglefene in the developing fetal brain leads to changes in the quantitative and qualitative characteristics of elements of sexual behavior in pubescent offspring.
Status:
Investigational
Source:
INN:nifuralide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Nifuralide, a 5-nitrofuran derivative, is an antibacterial agent. It was used for controlling Salmonella choleraesuis in swine. The mode of action of 5-nitrofuran analogues is based on red-ox biotransformation.

Showing 1361 - 1370 of 36626 results