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Search results for "JECFA|FUNCTIONAL CLASSIFICATION" in comments (approximate match)
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2013)
Source URL:
First approved in 2013
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Acetamide is found in red beetroot. Acetamide (or acetic acid amide or ethanamide), CH3CONH2, the amide of acetic acid, is a white crystalline solid in pure form. It is produced by dehydrating ammonium acetate. In the past, acetamide was used as a plasticiser and as a stabiliser. Molten acetamide was frequently used as a solvent in chemical synthesis. It also acts as a solubiliser; its mere addition renders many sparingly soluble compounds more soluble in water. Acetamide has been classified by theInternational Agency for Research on Cancer (IARC) as a Group 2B possible human carcinogen, as feeding trials on rats have shown an increase in liver carcinoma.
Status:
Possibly Marketed Outside US
Source:
21 CFR 346
(2020)
Source URL:
First approved in 2012
Source:
505G(a)(3)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
NCT04441528: Phase 4 Interventional Completed Seborrheic Blepharitis
(2018)
Source URL:
First approved in 2012
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
4-Carvomenthenol (Terpinen-4-ol) is an anti-inflammatory and antimicrobial agent. 4-Carvomenthenol is a fragrance ingredient used in decorative
cosmetics, fine fragrances, shampoos, toilet soaps and other toiletries as well as in non-cosmetic products such as household cleaners and detergents. Its use worldwide is in the region of 1–10
metric tonnes per annum.
The maximum skin level that results from the use of
4-carvementhenol in formulae that go into fine fragrances has
been reported to be 0.13%. 4-Carvomenthenol has been shown to have antiviral, antibacterial, antifungal, and insecticidal effects as well as antioxidant and anti-inflammatory activities. It is a putative anitcancer agent. 4-carvementhenol exerts its antitumor effects by triggering caspase-dependent apoptosis in human melanoma cells or by inducing necrotic cell death and cell-cycle arrest in mouse mesothelioma and melanomacell lines without affecting normal cells. Caspase-dependent mitochondrial dysfunction is the mechanism of terpinen-4-ol-induced apoptosis in nonsmall lung cancer cells. Down-regulation of Bcl-2, XIAP and survivin suggests that ter-pinen-4-ol increases the susceptibility of NSCLC cells toapoptosis induction. Notably, the ability of terpinen-4-ol to induce apoptosis in NSCLC cells is p53-dependent. It has also been shown that the growth of s.c. xenograft tumors was remarkably inhibited by intratumoral injection of terpinen-4-ol, indicating that the agent also has potential for clinical anticancer activity.
Status:
Possibly Marketed Outside US
Source:
21 CFR 348
(2013)
Source URL:
First approved in 2012
Source:
21 CFR 348
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
505G(a)(3)
(2024)
Source URL:
First approved in 2012
Source:
21 CFR 333E
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Citronellyl acetate, a monoterpene product of the secondary metabolism of plants is suitable for all kinds of fruity-floral compounds and flavor compositions. Citronellyl acetate is present mainly in Eucalyptus citriodora, which possesses different biological activities, including fungicidal, larvicidal and bactericidal. As a component of volatile oils from Pelargonium graveoleus Citronellyl acetate exhibited marginal antitumor activities. In addition, some studies revealed, that Citronellyl acetate possessed antinociceptive properties on acute pain. This this is achieved by the involvement of PKC, PKA, TRPV1, TRPA1, TRPM8, and ASIC in Citronellyl acetate's antinociceptive mechanism.
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2012)
Source URL:
First approved in 2012
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Possibly Marketed Outside US
Source:
505G(a)(3)
(2024)
Source URL:
First approved in 2012
Source:
21 CFR 333E
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Possibly Marketed Outside US
Source:
Dr Organic Virgin Coconut Oil Day Cream
Source URL:
First approved in 2012
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Status:
Possibly Marketed Outside US
Source:
505G(a)(3)
(2012)
Source URL:
First approved in 2012
Source:
505G(a)(3)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
Oxygen by Maniilaq Association
(2012)
Source URL:
First approved in 2012
Source:
Oxygen by Maniilaq Association
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)