U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1321 - 1330 of 34955 results

Status:
Investigational
Source:
INN:iolidonic acid
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Iolixanic Acid is triiodophenoxyalkoxyalkanoic acid derivative patented by Bracco Industria Chimica S.p.A. as diagnostic agent for cholecystography.
Status:
Investigational
Source:
INN:procodazole
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Procodazole is a non-specific active immunoprotective agent against viral and bacterial infections
Status:
Investigational
Source:
INN:ioseric acid
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Ioseric Acid is triiodoisophthalamic acid derivative patented by Schering A.-G. as x-ray contrast media
Status:
Investigational
Source:
INN:ibrolipim [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Lipoprotein lipase (LPL) is a rate-limiting enzyme that hydrolyzes circulating triglyceride-rich lipoproteins such as very low-density lipoproteins and chylomicrons. Otsuka Pharmaceutical Factory, Inc. synthesized the LPL activator NO-1886 (ibrolipim, [4-(4-bromo-2-cyano-phenylcarbamoyl)-benzyl]-phosphonic acid diethyl ester, CAS 133208-93-2). NO-1886 increased LPL mRNA and LPL activity in adipose tissue, myocardium and skeletal muscle, resulting in an elevation of postheparin plasma LPL activity and LPL mass. It was discovered, that this agent has a potentially beneficial for the treatment of hypertriglyceridemia, hypo-HDL cholesterolemia, and protection from atherosclerosis. In addition, this agent may be used in the treatment of obesity and obesity-linked health problems in postmenopausal women.
Status:
Investigational
Source:
INN:iotetric acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Iotetric Acid is triiodobenzoic acid derivative with potential application as neutrophil imaging in diagnosis of cystic fibrosis.
Status:
Investigational
Source:
INN:pirazmonam
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Pirazmonam is a potent anti-gram-negative monobactam that is differentiated from aztreonam by its high intrinsic activity against Ps. aeruginosa and good activity against Pseudomonas species. Pirazmonam has generally poor activity against gram-positive aerobic bacteria and anaerobic bacteria. Pirazmonam is a Trojan Horse molecule containing a b-lactam antibiotic that has been developed based on bacterial iron uptake systems. It features high structural similarity to aztreonam attached to a 3-hydroxy-4-pyridinone iron chelating group. Pirazmonam exhibited strong affinity to penicillin-binding protein 3 (PBP3) of Escherichia coli and moderate to negligible affinity to the other E. coli PBPs.
Status:
Investigational
Source:
INN:persilic acid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Persilic acid is a virucide, hemostatic, capillary protective agent. 0.1% aqueous solution of K salt is used as a fluorescent acid-base indicator.
Status:
Investigational
Source:
NCT01640808: Phase 3 Interventional Completed Hepatic Neoplasm Malignant Recurrent
(2012)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Peretinoin is an orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells. Peretinoin inhibits post-therapeutic recurrence of hepatocellular carcinoma via unclear mechanisms. The European Commission granted Orphan Drug designation for Kowa's peretinoin to treat hepatocellular carcinoma (HCC).
Status:
Investigational
Source:
INN:cinnamaverine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Cinnamaverine is an aminodiphenylacrylate, a smooth muscle relaxant and antispasmodic with some local anesthetic activity.
Status:
Investigational
Source:
NCT01644682: Phase 3 Interventional Completed Cost-effective and Sustainable Vector Control Methods Will be Established to Reduce VL in India, Bangladesh and Nepal
(2012)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Showing 1321 - 1330 of 34955 results