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Restrict the search for
angiotensin ii
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Methyl-1-testosterone(M1T)(17alpha-hydroxy-17-methyl-
5-androst-1-en-3-one) is a new designer steroid that is most likely produced to circumvent
the legal restrictions. It is advertised to be highly
anabolic and moderately androgenic and not convertible
to estrogens. However, in scientific literature, it was reported
to show anabolic properties of 25% and androgenic
properties of 50% compared with testosterone propionate
after im injection in castrated rats. In February
2006, Health Canada (Federal Department) warned consumers
not to use M1T-containing products because of
potentially serious health risks such as liver disorders and
hardening of the arteries. Since 2006, M1T is explicitly listed on the
World Anti-Doping Agency list of prohibited substances,
and therefore, its use by athletes is prohibited.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
The bioactive quinone Alpha-lapachone was originally isolated from the heartwood of trees of the Bignoniaceae family (Tabebuia sp). It can also be found in other families such as Verbenaceae, Proteaceae, Leguminosae, Sapotaceae, Scrophulariaceae, and Malvaceae. Alpha-Lapachone showed potent cytotoxicity against different cancer cell lines. Alpha-lapachone is an "irreversible" inhibitor of topoisomerase II. Alpha-lapachone demonstrated antibacterial activity against pathogenic organisms Staphylococcus aureus and Salmonella typhi and antifungal activity against Candida albicans and Trichophyton mentagrophytes.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
15-deoxy-Δ12,14-Prostaglandin J2 (15d-PGJ2) is a cyclopentanone prostaglandin and the agonist of endogenous PPAR gamma ligand, that is formed via the elimination of two molecules of water of prostaglandin D2. 15d-PGJ2 possesses anti-inflammatory effects. Experiments with animal models revealed, that 15d-PGJ2 may represent a potential therapeutic strategy in rheumatoid arthritis. Besides, 15d-PGJ2, given either systemically or locally in mice can control ongoing asthma pathological abnormalities, including eosinophil and neutrophil infiltration, mucus exacerbation, and lung remodeling triggered by ovalbumin. It was suggested, that potential exists to exploit 15d-PGJ2 as a therapeutic agent in asthma. It is known, the determination of individual prostaglandins, including 15d-PGJ2 in urine samples could improve the understanding of particular prostaglandins species under various physiological and pathological conditions. Recently was suggested the sensitive method for determination of 15d-PGJ2 and its application in human plasma samples of patients with diabetes.
