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Restrict the search for
angiotensin ii
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis. FR 180204 inhibited ERK1 and ERK2 with an IC50 value of 0.51 uM (Ki = 0.31 uM) and 0.33 uM (Ki = 0.14 uM), respectively. FR 180204 may be useful as a therapeutic agent for the treatment of cancer, immune diseases, ischemic brain injury, and obesity. In a mouse model of dengue virus (DENV) infection, FR 180204 limits hepatocyte apoptosis, reduces DENV-induced liver injury, and improves Clinical parameters.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Veratridine (VTD), an alkaloid derived from the Liliaceae plant shows anti-tumor effects. Veratridine is also an agent that opens voltage dependent Na+ channels, blocks Na+ channel activation, and induces Ca2+ influx. The compound has been observed to be an alkaloid neurotoxin used to amplify sodium permeability. Studies report that Veratridine can trigger exocytosis and induce Ca2+ oscillations. Furthermore, Veratridine has been shown to effect the mitochondrial respiratory chain complexes, induce release of noradrenaline, and increase superoxide anion production. Veratridine competes with BTX binding in a mutually exclusive manner. However, the pharmacological effects of veratridine on Na+ channels are quite different
from those of BTX. First, veratridine reduces the single
Na+ channel conductance drastically whereas BTX does not.
Veratridine therefore is regarded as a partial agonist and BTX
as a full agonist of Na+ channels. Second, under voltage clamp
conditions BTX binds practically irreversibly to Na+
channels whereas veratridine readily dissociates from its binding
site. Both of these drugs, however, bind preferentially
to the open state of Na+ channels. The BTX resistant
Na+ channels in Phyllobates frogs remain sensitive to veratridine. The ceveratrum alkaloids, including Veratridine, have a characteristic hypotensive effect not directly involving the CNS. They slow the heart and lower arterial blood pressure by reflexly stimulating medullary vasomotor centers without decreasing cardiac output (Bezold–Jarisch effect). These agents were introduced in the 1950s as antihypertensive agents; however, they were found to have a narrow therapeutic index and their use was discontinued.
Cupric octanoate is a fungicide and bactericide used to control many plant diseases. Cupric octanoate is classified as category III (caution) for acute oral, dermal and inhalation toxicity and category IV for eye and skin irritation.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
