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Restrict the search for
phenyl aminosalicylate
to a specific field?
Status:
Possibly Marketed Outside US
Source:
Amidefrine mesylate
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Withdrawn
Source:
Alphacetylmethadol
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Alphacetylmethadol (INN), aka α-acetylmethadol (AAM), is a synthetic opioid analgesic. Its levorotary enantiomer, levacetylmethadol, is an FDA-approved treatment for opioid addiction. Alphacetylmethadol is very similar in structure to methadone, a widely-prescribed treatment for opioid addiction. In the United States, it is a Schedule I controlled substance under the Controlled Substances Act with an ACSCN of 9603 and a 2013 annual manufacturing quota of 2 grams. Studies in rats indicate that alphacetylmethadol also evokes the heroin-like discriminative stimulus effects.
Status:
Withdrawn
Source:
Diethylaminoethoxyhexestrol [Japan]
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Diethylaminoethoxyhexestrol is a coronary dilating agent, approved for the treatment of angina in 1958 and marketed under tradename Coralgil. Diethylaminoethoxyhexestrol was withdrawn from the market because of drug-related phospholipidosis in liver, spleen and other tissues. Studies indicate that lipidosis is caused by the accumulation of the drug in lysosomes and inhibition of phospholipase A.
Status:
Withdrawn
Source:
Aminorex fumarate
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Aminorex is an anorectic stimulant drug. Aminorex inhibits norepinephrine and dopamine transporters with IC50 of 0.33 and 0.85 uM. It was briefly available as an appetite suppressant in the 1960s in Switzerland, Germany, and Austria, but was found to cause pronounced vasoconstriction in the pulmonary vasculature, and was withdrawn from the market in 1972 due to several cases of fatal and life-threatening pulmonary hypertension. In the USA aminorex is an illegal schedule I drug.
Status:
US Approved Rx
(1999)
Source:
ANDA075528
(1999)
Source URL:
First approved in 1967
Source:
CLOMID by SANOFI AVENTIS US
Source URL:
Class:
MIXTURE
Targets:
Conditions:
Clomiphene (CLOMID®) is a triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. It is an orally administered, nonsteroidal, ovulatory stimulant. Clomiphene (CLOMID®) is a mixture of two geometric isomers [cis (zuclomiphene) and trans (enclomiphene)] containing between 30% and 50% of the cis-isomer. Clomiphene (CLOMID®) initiates a series of endocrine events culminating in a preovulatory gonadotropin surge and subsequent follicular rupture. The first endocrine event in response to a course of clomiphene therapy is an increase in the release of pituitary gonadotropins. This initiates steroidogenesis and folliculogenesis, resulting in growth of the ovarian follicle and an increase in the circulating level of estradiol. Following ovulation, plasma progesterone and estradiol rise and fall as they would in a normal ovulatory cycle.
Status:
Investigational
Source:
INN:afimoxifene [INN]
Source URL:
Class:
MIXTURE
Conditions:
Hydroxytamoxifen (Afimoxifene) is an active metabolite of tamoxifen exerting estrogen receptor modulatory function. In addition, hydroxytamoxifen binds to regulates transcriptional activity of the estrogen-related receptor gamma. ASCEND Therapeutics, Inc. was developing TamoGel (4-hydroxytamoxifen gel) for a variety of estrogen-dependent conditions, including breast cancer, cyclic breast pain and gynecomastia.
Status:
Other
Class:
MIXTURE
Status:
Other
Class:
MIXTURE
Status:
Other
Class:
MIXTURE
Status:
Other
Class:
MIXTURE
