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Restrict the search for
beta carotene
to a specific field?
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Elarofiban is a novel nonpeptide glycoprotein IIb/IIIa (GPIIb/IIIa) antagonist. It inhibits thrombin-induced platelet aggregation in human gel-filtered platelets and platelet aggregation in human platelet-rich plasma (PRP) in response to collagen, arachidonic acid, ADP, and SFLLRN-NH(2). Elarofiban had adequate oral pharmacokinetics in dogs and excellent oral pharmacodynamics. Elarofiban has been in phase II clinical trials for the treatment of myocardial infarction and thrombosis. However, this research has been discontinued.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Galocitabine is an orally available 5-fluorouracil (5-FU) prodrug with potential antineoplastic activity. Upon administration, galocitabine is converted to 5’-deoxy-fluorocytidine (5’-DFCR) by acylamidase in the liver and is then converted to 5’-DFUR by cytidine deaminase. Efficient conversion of galocitabine to 5-FU is necessary for galocitabine to have a therapeutic effect. 5-FU is further metabolized into other cytotoxic metabolites that interfere with RNA and DNA synthesis via inhibition of thymidylate synthase. As a result, this agent eventually inhibits tumor cell growth.
Status:
Investigational
Class (Stereo):
CHEMICAL (ABSOLUTE)
Sucralox is a saccharated aluminum hydroxide patented by Combe, Inc. as antacid agent. Sucralox shows potent antacid properties in vitro and in vivo. Currently Sucralox is used to support gastric and intestinal health in horses.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Cetocycline (formerly chelocardin or cetotetrine) is tetracycline derivative with potent antibacterial activity against a number of Gram-positive and Gram-negative multi-resistant pathogens. Cetocycline was found to be more active than tetracycline against many clinical isolates of aerobic gram-negative bacilli, but is less active against staphylococci, and has no activity against Pseudomonas. At low concentrations, like classical tetracyclines, chelocardin induces the proteomic signature for peptidyl transferase inhibition demonstrating that protein biosynthesis inhibition is the dominant physiological challenge. At higher concentrations B. subtilis mainly responds to membrane stress indicating that at clinically relevant concentrations the membrane is the main antibiotic target of chelocardin.
Status:
Investigational
Source:
USAN:DIFLUCORTOLONE PIVALATE [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Diflucortolone pivalate is a glucocorticoid drug. It might be used as anti-inflammatory and anti-allergic agent.
Class (Stereo):
CHEMICAL (RACEMIC)
Ericolol is an antagonist of beta-adrenoreceptors. It exerts antihypertensive, antianginal and antiarrhythmic properties.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Ersentilide (CK-3579 or HE93) is a blocker of beta1-adrenergic receptors and potassium channels. It exerts class III antiarrhythmic activity. It prevents ventricular fibrillation in a canine model of lethal arrhythmias.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Furbucillin is a synthetic antibacterial agent that has never been marketed. Information about the current use of this drug is not available.
Status:
Investigational
Source:
USAN:FLUPREDNISOLONE VALERATE [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
The information related to the biological or pharmacological application of fluprednisolone valerate is absent.
Status:
Investigational
Source:
NCT00090090: Phase 2 Interventional Completed Mantle Cell Lymphoma
(2004)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Elsamitrucin is a heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. It demonstrated a broad spectrum of in vitro cytotoxicity against tumor cell lines. According to the results of Phase II trials elsamitrucin is not an active drug in patients with metastatic breast cancer, colorectal cancer, non-small cell lung cancer or ovarian cancer, however, it showed modest activity in patients with relapsed or refractory non-Hodgkin's lymphoma.
