Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H22FN3O8 |
| Molecular Weight | 439.3917 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(=CC(OC)=C1OC)C(=O)NC2=NC(=O)N(C=C2F)[C@@H]3O[C@H](C)[C@@H](O)[C@H]3O
InChI
InChIKey=TVYPSLDUBVTDIS-FUOMVGGVSA-N
InChI=1S/C19H22FN3O8/c1-8-13(24)14(25)18(31-8)23-7-10(20)16(22-19(23)27)21-17(26)9-5-11(28-2)15(30-4)12(6-9)29-3/h5-8,13-14,18,24-25H,1-4H3,(H,21,22,26,27)/t8-,13-,14-,18-/m1/s1
Galocitabine is an orally available 5-fluorouracil (5-FU) prodrug with potential antineoplastic activity. Upon administration, galocitabine is converted to 5’-deoxy-fluorocytidine (5’-DFCR) by acylamidase in the liver and is then converted to 5’-DFUR by cytidine deaminase. Efficient conversion of galocitabine to 5-FU is necessary for galocitabine to have a therapeutic effect. 5-FU is further metabolized into other cytotoxic metabolites that interfere with RNA and DNA synthesis via inhibition of thymidylate synthase. As a result, this agent eventually inhibits tumor cell growth.
Approval Year
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NCI_THESAURUS |
C1557
Created by
admin on Fri Dec 15 15:37:05 GMT 2023 , Edited by admin on Fri Dec 15 15:37:05 GMT 2023
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100000084513
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X9788XI79O
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6806
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65950
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DTXSID10154189
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C73254
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CHEMBL2106813
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124012-42-6
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SUB07875MIG
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PRIMARY |
ACTIVE MOIETY
