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m cariprazine
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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
ORY-1001 (known as RG 6016) is a Lysine Specific Demethylase 1 (LSD1, also known as KDM1A) inhibitor (IC50 <20nM) with high selectivity against related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B >100uM, SMOX 7uM). LSD1 is a histone eraser enzyme that removes methyl groups, specifically mono and demethylated H3K4 and H3K9, and by doing so regulates the expression of many genes important in the onset and progression of diseases such as cancer and neurodegenerative disorders. ORY-1001 is a lead drug candidate of Oryzon Genomics S.A. under development for the treatment of acute myeloid leukemia (AML) – phase I/II and small cell lung cancer (SCLC) – phase I. Oryzon has made significant progress with ORY-1001 over the past years.
Sorbose is a ketose belonging to the group of sugars known as monosaccharides. It has a sweetness that is equivalent to sucrose (table sugar). L-Sorbose was also regarded as an alternative sugar, as it didn’t induce hyperglycemia or insulinemia, but mice which were fed by this compound had adverse effects: increased organ weights (liver, kidney, hearts)
![Structure of rel-trans-4-Amino-N-[(1R,2S)-2-phenylcyclopropyl]cyclohexanemethanamine](/img/7f042294-00c8-e8e9-e33d-973d19efbf27.svg?size=200&context=jypomxscny)
