SORBOSE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H12O6
Molecular Weight	180.1561
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC[C@H](O)[C@@H](O)[C@H](O)C(=O)CO

InChI

InChIKey=BJHIKXHVCXFQLS-OTWZMJIISA-N

InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3,5-9,11-12H,1-2H2/t3-,5+,6+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C6H12O6
Molecular Weight	180.1561
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://books.google.ru/books?id=rH_A3CGur2sC&pg=PA58&lpg=PA58&dq=L-sorbose+is+used&source=bl&ots=Ker0HrZ3Wt&sig=QevfFXCpWrXJFuJ0lsxX7UkFt-s&hl=ru&sa=X&ved=0ahUKEwjf1JfOlqnPAhWBPxQKHR-KBZc4ChDoAQg4MAg#v=onepage&q=L-sorbose%20is%20used&f=false

Sorbose is a ketose belonging to the group of sugars known as monosaccharides. It has a sweetness that is equivalent to sucrose (table sugar). L-Sorbose was also regarded as an alternative sugar, as it didn’t induce hyperglycemia or insulinemia, but mice which were fed by this compound had adverse effects: increased organ weights (liver, kidney, hearts)

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diabetes mellitus 93 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2051234	Preventing		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Prevention of the incidence of diabetes by dietary sorbose in nonobese diabetic mice.	1991-07	2051234
Metabolism of L-sorbose in the rat and the effect of the intestinal microflora on its utilization both in the rat and in the human.	1979	424083
Inhibition of glycolysis by L-sorbose in dog erythrocytes.	1978-06-15	658309

Patents

Sample Use Guides

In Vivo Use Guide

for mice: 200 g/kg diet

Route of Administration: Oral

In Vitro Use Guide

L-sorbose acts directly on dog erythrocytes to induce hemolysis. L-sorbose depresses lactate formation in dog hemolysates from glucose, mannose and fructose but not from glucose-6-phosphate and galactose, thus L-sorbose interacts with glycolysis at the level of the hexokinase.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:34:13 GMT 2025` Edited by `admin` on `Mon Mar 31 17:34:13 GMT 2025`
Record UNII	NV2001607Y
Record Status	`FAILED`
Record Version

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Name

Type

Language

SORBOSE

Systematic Name

English

NSC-97195

Preferred Name

English

SORBOSE, L-

Systematic Name

English

SORBOSE [HSDB]

Common Name

English

SORBIN

Common Name

English

L-SORBOSE

Systematic Name

English

SORBOSE [MI]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 186.1839