SORBOSE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H12O6
Molecular Weight	180.1559
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC[C@H](O)[C@@H](O)[C@H](O)C(=O)CO

InChI

InChIKey=BJHIKXHVCXFQLS-OTWZMJIISA-N

InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3,5-9,11-12H,1-2H2/t3-,5+,6+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C6H12O6
Molecular Weight	180.1559
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://books.google.ru/books?id=rH_A3CGur2sC&pg=PA58&lpg=PA58&dq=L-sorbose+is+used&source=bl&ots=Ker0HrZ3Wt&sig=QevfFXCpWrXJFuJ0lsxX7UkFt-s&hl=ru&sa=X&ved=0ahUKEwjf1JfOlqnPAhWBPxQKHR-KBZc4ChDoAQg4MAg#v=onepage&q=L-sorbose%20is%20used&f=false

Sorbose is a ketose belonging to the group of sugars known as monosaccharides. It has a sweetness that is equivalent to sucrose (table sugar). L-Sorbose was also regarded as an alternative sugar, as it didn’t induce hyperglycemia or insulinemia, but mice which were fed by this compound had adverse effects: increased organ weights (liver, kidney, hearts)

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diabetes mellitus 91 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2051234	Preventing		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Inhibition of glycolysis by L-sorbose in dog erythrocytes.	1978 Jun 15	658309
Metabolism of L-sorbose in the rat and the effect of the intestinal microflora on its utilization both in the rat and in the human.	1979	424083
Prevention of the incidence of diabetes by dietary sorbose in nonobese diabetic mice.	1991 Jul	2051234

Patents

Sample Use Guides

In Vivo Use Guide

for mice: 200 g/kg diet

Route of Administration: Oral

In Vitro Use Guide

L-sorbose acts directly on dog erythrocytes to induce hemolysis. L-sorbose depresses lactate formation in dog hemolysates from glucose, mannose and fructose but not from glucose-6-phosphate and galactose, thus L-sorbose interacts with glycolysis at the level of the hexokinase.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 14:59:23 GMT 2023` Edited by `admin` on `Fri Dec 15 14:59:23 GMT 2023`
Record UNII	NV2001607Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SORBOSE

Systematic Name

English

SORBOSE, L-

Systematic Name

English

SORBOSE [HSDB]

Common Name

English

SORBIN

Common Name

English

L-SORBOSE

Systematic Name

English

NSC-97195

Code

English

SORBOSE [MI]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 186.1839