beta-apo-Oxytetracycline is the degradation product of Oxytetracycline. It exhibits greater toxicity compared with the parent compound. The toxic effects of beta-apo-Oxytetracycline treatment could damage liver and kidney tissues of rats, as well as lead to the degeneration and necrosis in the hepatocytes.

Pifithrin-alpha is a small molecule p53 functional inhibitor reported to behave like an antiapoptotic agent in neurodegenerative models. Pifithrin-alpha is a prodrug that under physiological conditions spontaneously undergoes ring closure to yield pifithrin-beta. Pifithrin-beta demonstrated antiproliferative and neuroprotective effects in vitro. Pifithrin-beta is able to activate the aryl hydrocarbon receptor (AhR) in a complete independent way of the p53 inhibition.