Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H22N2O8 |
| Molecular Weight | 442.4187 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(OC(=O)C2=C(O)C3=C(O)C=CC=C3C(C)=C12)[C@]4([H])[C@@H](O)C(=O)C(C(N)=O)=C(O)[C@H]4N(C)C
InChI
InChIKey=DRKMHDAKULCOKQ-VPZFNDQJSA-N
InChI=1S/C22H22N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)20(32-22(12)31)13-15(24(2)3)17(27)14(21(23)30)19(29)18(13)28/h4-6,13,15,18,20,25-28H,1-3H3,(H2,23,30)/t13-,15-,18+,20-/m0/s1
beta-apo-Oxytetracycline is the degradation product of Oxytetracycline. It exhibits greater toxicity compared with the parent compound. The toxic effects of beta-apo-Oxytetracycline treatment could damage liver and kidney tissues of rats, as well as lead to the degeneration and necrosis in the hepatocytes.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Study of the mechanism of action of minocycline and of certain other tetracycline group compounds]. | 1976 Mar |
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| Application of reversed-phase liquid chromatography and prepacked C18 cartridges for the analysis of oxytetracycline and related compounds. | 1996 Mar 3 |
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| Susceptibility of Escherichia coli and Enterococcus faecium isolated from pigs and broiler chickens to tetracycline degradation products and distribution of tetracycline resistance determinants in E. coli from food animals. | 2003 Aug 29 |
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| Determination of oxytetracycline and its degradation products by high-performance liquid chromatography-tandem mass spectrometry in manure-containing anaerobic test systems. | 2003 Jan 5 |
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| Characterisation of the abiotic degradation pathways of oxytetracyclines in soil interstitial water using LC-MS-MS. | 2003 Mar |
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| Quantitative analysis of oxytetracycline and its impurities by LC-MS-MS. | 2004 Feb 4 |
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| Tetracycline residues and tetracycline resistance genes in groundwater impacted by swine production facilities. | 2006 |
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| C(18) columns for the simultaneous determination of oxytetracycline and its related substances by reversed-phase high performance liquid chromatography and UV detection. | 2007 Jan 17 |
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| Determination and fate of oxytetracycline and related compounds in oxytetracycline production wastewater and the receiving river. | 2008 Jan |
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| A liquid chromatography-tandem mass spectrometry confirmatory assay for the simultaneous determination of several tetracyclines in milk considering keto-enol tautomerism and epimerization phenomena. | 2009 Dec 10 |
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| The degradation of oxytetracycline during thermal treatments of chicken and pig meat and the toxic effects of degradation products of oxytetracycline on rats. | 2015 May |
Patents
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| Code System | Code | Type | Description | ||
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18751-99-0
Created by
admin on Sat Dec 16 09:54:31 GMT 2023 , Edited by admin on Sat Dec 16 09:54:31 GMT 2023
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PRIMARY | |||
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1361013-49-1
Created by
admin on Sat Dec 16 09:54:31 GMT 2023 , Edited by admin on Sat Dec 16 09:54:31 GMT 2023
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DTXSID601315222
Created by
admin on Sat Dec 16 09:54:31 GMT 2023 , Edited by admin on Sat Dec 16 09:54:31 GMT 2023
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7HSY5812F9
Created by
admin on Sat Dec 16 09:54:31 GMT 2023 , Edited by admin on Sat Dec 16 09:54:31 GMT 2023
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54694061
Created by
admin on Sat Dec 16 09:54:31 GMT 2023 , Edited by admin on Sat Dec 16 09:54:31 GMT 2023
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PRIMARY |
SUBSTANCE RECORD
