SAMARIUM SM-153 is a β- and γ-emitter with a physical half-life around 46.8 hours. Sm-153 treatment is recommended for patients with multiple bone metastases with the osteoblastic component, regardless of the primary tumor’s location. This compound was used in prostate cancer. It was shown that the small influence of Sm-153 on hematological parameters in patients treated with Sm-153, because of the high affinity of Sm-153 to osteoblastic metastases, and of the effect of low concentration of radionuclide in healthy bone tissue.

Iodine-125 is an iodine radioisotope that is used in biological analyzes, imaging of nuclear medicine and in radiation therapy as brachytherapy for the treatment of a number of conditions, including prostate cancer, uveal melanomas, and brain tumors. Because of its relatively long half-life and the emission of low-energy photons, which can be detected with gamma counter detectors, Iodine-125 is the preferred isotope for labeling antibodies in radioimmunoassay and other procedures for counting gamma radiation with the participation of proteins outside the body. The same properties of the isotope make it useful for brachytherapy and for some nuclear medicine scanning procedures in which it is attached to proteins, and where a longer half-life than I-123 is required for a test of several days. Iodine-125 can be used when imaging the thyroid gland, but iodine-123 is preferred for this purpose because of the better penetration of radiation and a shorter half-life. For radiation ablation of tissues that absorb iodine (for example, the thyroid gland) or that absorb iodine-containing radiopharmaceutical, the preferred isotope is iodine-131. Iodine-125 is useful for determining glomerular filtration rate in the diagnosis or monitoring of patients with kidney disease.

Scopoletin is a coumarin that can be isolated from plants of the genus Scopolia. It has been identified as a natural antifungal compound. Scopoletin was also demonstrated to be an MAO inhibitor capable of increasing dopamine levels in mice and is therefore of potential interest for developing treatments for neurodegenerative diseases.

Americium is a radioactive metallic element with atomic number 95 and element symbol Am. It's the only synthetic element encountered in everyday life, in minute quantities in ionization-type smoke detectors. Americium was first synthesized and identified in 1944 by Glenn T. Seaborg, Ralph James, L Morgan, and Albert Ghiorso at the University of California, Berkeley as part of the Manhattan Project. The element was produced using a 60-inch cyclotron. Americium is a shiny silver radioactive metal. All isotopes of this element are radioactive. The isotope with the longest half-life is americium-243, which has a half-life of 7370 years. The most common isotopes are americium-241, with a half-life of 432.7 years, and americium-243. Americium-242 is also known, with a half-life of 141 years. In total, 19 isotopes and 8 nuclear isomers have been characterized. The isotopes variously undergo alpha, beta, and gamma decay. EPA Facts AboutAmericium-241EPA Facts About Americium-241 July 2002 What is americium-241? Americium is a man-made radioactive metal that exists as a solid under normal conditions. Americium is produced when plutonium absorbs neutrons in nuclear reactors and nuclear weapons tests. Americium occurs in several forms called isotopes. The most common isotope is americium-241. Americium when blended with beryllium is used as a neutron source in the testing of machinery and in thickness gauges in the glass industry. Americium also is used as a radiation source in medical diagnostic devices and in research. Possible uses are in medicine where gamma emission of Am-241 has allowed the deter-mination of mineral content of bones, lipid content of soft tissues, and body composition. Americium is commonly used in minute amounts in smoke detectors as an ionization source. However this isotope is extremely expensive to produce in usable quantities. There is no known biological role of americium in living organisms. It's generally considered toxic because of its radioactivity.

Vintriptol, a tryptophan ester of vinblastine, was developed as an antitumor drug. Vintriptol participated in a phase I clinical trial for the treatment of non-small cell lung cancer. As a result, was found a recommended dose for stage II. However, the further development of vintriptol was discontinued.

Patupilone is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, Patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Epothilone B may cause complete cell-cycle arrest. Patupilone failed a phase III trial for ovarian cancer in 2010.