U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Showing 91 - 100 of 5,117 results

Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)

Dibusadol is an analgesic agent.
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

m-Chlorophenylpiperazine (meta-chlorophenylpiperazine or mCPP) is a psychoactive substance, which is illegal in many countries but can be found on the black market. It induces endocrine, neurological and psychiatric effects. mCPP is a partial agonist...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)



(-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine ((-)-3-PPP, also known as preclamol) has a dual action towards to dopamine D2 autoreceptor: it activates it and also acts concomitantly as an antagonist at postsynaptic DA receptors. It was shown, that (-)...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)

As a narcotic antagonist similar in action to naloxone, DIPRENORPHINE is used to remobilize animals after analgesia by super-potent opioid analgesics such as etorphine and carfentanil. It is not used in humans. Diprenorphine binds approximately equal...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational

Class (Stereo):
CHEMICAL (RACEMIC)



Adaprolol is a beta-adrenergic antagonist that is being developed as a topical agent to treat glaucoma. Adaprolol demonstrated a safer cardiovascular profile, especially in the population over 70 years old. It was in Phase II clinical trials for the ...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)

Terbogrel, an agent having two pharmacodynamic actions, namely inhibition of thromboxane A2 synthase and antagonism of the thromboxane A2 receptor. The antithrombotic effect of terbogrel was dose-dependent and was associated with enhanced prostacycli...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)

Mepiprazole is a psychotropic pyrazole derivative. Mepiprazole is a serotonin reuptake inhibitor and adrenolytic. In clinical studies, it demonstrated anxiolytic properties.
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)

Imanixil (also known as HOE-402) was developed as a potent cholesterol-lowering compound, which inhibits VLDL production, and consequently attenuates atherosclerosis development. This drug participated in phase I clinical trial for the treatment of h...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)