IMANIXIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H17F3N6O2
Molecular Weight	394.3511
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)CN(C(=O)N1)C2=NC=C(C(=O)NC3=CC=CC(=C3)C(F)(F)F)C(N)=N2

InChI

InChIKey=FUSNOPLQVRUIIM-UHFFFAOYSA-N

InChI=1S/C17H17F3N6O2/c1-16(2)8-26(15(28)25-16)14-22-7-11(12(21)24-14)13(27)23-10-5-3-4-9(6-10)17(18,19)20/h3-7H,8H2,1-2H3,(H,23,27)(H,25,28)(H2,21,22,24)

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Description
Sources: https://adisinsight.springer.com/drugs/800002688 | https://www.ncbi.nlm.nih.gov/pubmed/12007578

Imanixil (also known as HOE-402) was developed as a potent cholesterol-lowering compound, which inhibits VLDL production, and consequently attenuates atherosclerosis development. This drug participated in phase I clinical trial for the treatment of hyperlipidemia, however, this study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Hypolipidemic activity of HOE-402 is mediated by stimulation of the LDL receptor pathway.	1993 Jul	8318502
Cholesterol lowering action of HOE 402 in the normolipidemic and hypercholesterolemic golden Syrian hamster.	1996 Jan 5	8555258
HOE 402 lowers serum cholesterol levels by reducing VLDL-lipid production, and not by induction of the LDL receptor, and reduces atherosclerosis in wild-type and LDL receptor-deficient mice.	2002 May 1	12007578

Name

Type

Language

IMANIXIL

Official Name

English

4-AMINO-2-(4,4-DIMETHYL-2-OXO-1-IMIDAZOLIDINYL)-A,A,A-TRIFLUORO-5-PYRIMIDINECARBOXY-M-TOLUIDIDE

Common Name

English

imanixil [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29703