U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 91 - 100 of 304 results

5-(2-Aminopropyl)indole (5-API, 5-IT, PAL-571) is a psychoactive phenethylamine derivative with empathogenic effects used for recreational purposes. 5-(2-Aminopropyl)indole, originally synthesized as a stimulant in the 1960s now joins the list of psychoactive substances and may to be one of the newest MDMA replacements. 5-(2-Aminopropyl)indole acts as a triple monoamine releasing agent and also as selective MAO-A inhibitor.
Norfluoxetine is an active N-desmethyl metabolite of the antidepressant fluoxetine that inhibits serotonin uptake. Norfluoxetine is selective serotonin reuptake inhibitor (SSRI) but little is known about its pharmacological actions. Seproxetine (S- Norfluoxetine) was being investigated by Eli Lilly as an antidepressant but development was never completed and the drug was never marketed.