Lotilaner is a member of the isoxazoline family, a novel class of parasiticides that targets the nerve receptors of ticks and fleas. This veterinary medicinal product provides immediate and persistent killing activity for 1 month for fleas (Ctenocephalides felis and C. canis) and ticks (Rhipicephalus sanguineus, Ixodes ricinus, I. hexagonus and Dermacentor reticulatus). The veterinary medicinal product can be used as part of a treatment strategy for the control of flea allergy dermatitis. During clinical testing, no interactions between Lotilaner chewable tablets and routinely used veterinary medicinal products were observed.