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Restrict the search for
"ANANDAMIDE"
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Glyceryl 2-linoleate is a fatty acid derivative. It inhibits monoacylglycerol lipase and fatty acid amide hydrolase activity. Glyceryl 2-linoleate enhanced a 2-Arachidonoyl-glycerol inhibition of tumor necrosis factor alpha production in murine macrophages when applied with 2-Arachidonoyl-glycerol. Initially, it was found that Glyceryl 2-linoleate potentiated the apparent binding of 2-Arachidonoyl-glycerol to cannabinoid receptors CB1 and CB2. However, later research revealed that in no case do the lipid Glyceryl 2-linoleate acts as entourage compounds for 2-Arachidonoyl-glycerol. Increase in Glyceryl 2-linoleate plasma concentrations was observed in cocaine subjects diagnosed with psychiatric comorbidity.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Phenylmethanesulfonyl fluoride is an irreversible inhibitor of serine proteases commonly used in the preparation of cell lysates. Phenylmethanesulfonyl fluoride has been used as a supplement in nuclear protein extraction and inhibitor of cholesterol esterase (CE) and pseudocholinesterase (PCE). Administration of PMSF produces analgesia unrelated to its anticholinesterase effect and prolongs the analgesic effect of centrally administered β-endorphin. The physiological and toxicological properties of this compound have not been evaluated in humans.
Status:
US Previously Marketed
Source:
Oleic Acid U.S.P.
(1921)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Elaidic acid is the 9-trans isomer of oleic acid. It is a monounsaturated trans-fatty acid, which can be found in partially hydrogenated cooking oils. It was revealed, that elaidic acid inhibits HHT and HETE formation in human platelets incubated with arachidonic acid. Also was shown, that trans oleic acid increased plasma CETP activity, which increases low-density lipoprotein (LDL) cholesterol and decreases high-density lipoprotein (HDL).
Status:
Possibly Marketed Outside US
Source:
LipoGel CR Base by Southeastern Medical Technologies
(2013)
Source URL:
First approved in 2013
Source:
LipoGel CR Base by Southeastern Medical Technologies
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Status:
Investigational
Source:
NCT03534063: Not Applicable Interventional Completed Pain, Postoperative
(2018)
Source URL:
Class:
PROTEIN
