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Primary Target

store-operated calcium entry

4

Histamine H1 receptor

316

Dopamine D2 receptor

311

DNA

282

Serotonin 2a (5-HT2a) receptor

237

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US Previously Marketed

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Approval Year

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1921

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Condition

Constipation

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Treatment Modality

Curative

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Originator

Baeyer, A.

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Substance Class

Chemical

4

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Code System

FDA UNII

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PUBCHEM

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CAS

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EPA CompTox

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CHEBI

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ATC Level 1

ALIMENTARY TRACT AND METABOLISM

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ATC Level 2

LAXATIVES

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ATC Level 3

LAXATIVES

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ATC Level 4

Contact laxatives

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Substance Form

Principal Form

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Salts, Hydrates, Esters, etc.

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Showing 1 - 4 of 4 results

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6-BROMO-(2-CHLOROPHENYL) QUINAZOLINE-2-ONE

SDR4PJJ2KD

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NF-kappa B signaling pathway

store-operated calcium entry

SKF-96365 FREE BASE

I61V87164A

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Status:

Other

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

store-operated calcium entry

SKF-96365

33BI32858P

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Status:

Other

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

store-operated calcium entry

PHENOLPHTHALEIN

6QK969R2IF

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

store-operated calcium entry

potassium ion export

Conditions:

Phenolphthalein is a chemical compound often used as an indicator in acid-base titrations. For this application, it turns colorless in acidic solutions and pink in basic solutions. In medicine, phenolphtaleine was used as a laxative, but is now being...

removed from over-the-counter laxatives because of concerns over carcinogenicity. The mechanism of action of phenolphthalein is poorly understood. It is speculated that laxative effect of phenolphthalein in part to be mediated by the efflux of potassium from cells.

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