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Primary Target

monoamine oxidase activity

6

Histamine H1 receptor

315

Dopamine D2 receptor

297

DNA

278

Bacterial penicillin-binding protein

233

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Sterling Drug

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Chemical

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CAS

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EPA CompTox

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FDA UNII

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CHEBI

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Showing 1 - 6 of 6 results

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HYCANTHONE

2BXX5EVN2A

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

monoamine oxidase activity

DNA-(apurinic or apyrimidinic site) lyase

UniProtKB: Q71SU7 (Carboxylic ester hydrolase)

Conditions:

Schistosomiasis

Hycanthone is a thioxanthene derivative of lucanthone with anti-schistosomal activity and potential antineoplastic activity. It was clinically available for the treatment of human schistosomiasis. Anti-helmintic action relies on its ability to inhibi...

t worm monoamine oxidase and cholinesterases. Hycanthone produced immediate side effects such as hepatotoxicity and gastrointestinal disturbances, and was consequently withdrawn. Hycanthone inhibits apurinic endonuclease-1 (APE1) by direct protein binding. Hycanthone was used in the 1980s as antitumor agents, it was pulled out of Phase II trials.

6-(2-AMINOPROPYL)INDOLE

27230C15B7

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Status:

Other

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

monoamine oxidase activity

HYCANTHONE MESYLATE

48830NW22A

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

monoamine oxidase activity

DNA-(apurinic or apyrimidinic site) lyase

UniProtKB: Q71SU7 (Carboxylic ester hydrolase)

Conditions:

Schistosomiasis

Hycanthone is a thioxanthene derivative of lucanthone with anti-schistosomal activity and potential antineoplastic activity. It was clinically available for the treatment of human schistosomiasis. Anti-helmintic action relies on its ability to inhibi...

t worm monoamine oxidase and cholinesterases. Hycanthone produced immediate side effects such as hepatotoxicity and gastrointestinal disturbances, and was consequently withdrawn. Hycanthone inhibits apurinic endonuclease-1 (APE1) by direct protein binding. Hycanthone was used in the 1980s as antitumor agents, it was pulled out of Phase II trials.

HYCANTHONE ETHANESULFONATE

IOB67KGQ3N

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

monoamine oxidase activity

DNA-(apurinic or apyrimidinic site) lyase

UniProtKB: Q71SU7 (Carboxylic ester hydrolase)

Conditions:

Schistosomiasis

Hycanthone is a thioxanthene derivative of lucanthone with anti-schistosomal activity and potential antineoplastic activity. It was clinically available for the treatment of human schistosomiasis. Anti-helmintic action relies on its ability to inhibi...

t worm monoamine oxidase and cholinesterases. Hycanthone produced immediate side effects such as hepatotoxicity and gastrointestinal disturbances, and was consequently withdrawn. Hycanthone inhibits apurinic endonuclease-1 (APE1) by direct protein binding. Hycanthone was used in the 1980s as antitumor agents, it was pulled out of Phase II trials.

HYCANTHONE SULFAMATE

6QS8DNR44V

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

monoamine oxidase activity

DNA-(apurinic or apyrimidinic site) lyase

UniProtKB: Q71SU7 (Carboxylic ester hydrolase)

Conditions:

Schistosomiasis

Hycanthone is a thioxanthene derivative of lucanthone with anti-schistosomal activity and potential antineoplastic activity. It was clinically available for the treatment of human schistosomiasis. Anti-helmintic action relies on its ability to inhibi...

t worm monoamine oxidase and cholinesterases. Hycanthone produced immediate side effects such as hepatotoxicity and gastrointestinal disturbances, and was consequently withdrawn. Hycanthone inhibits apurinic endonuclease-1 (APE1) by direct protein binding. Hycanthone was used in the 1980s as antitumor agents, it was pulled out of Phase II trials.

6-(2-AMINOPROPYL)INDOLE MALEATE

M7C77J017A

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Status:

Other

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

monoamine oxidase activity

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