Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
PF-04449913 is a potent and selective inhibitor of the Hh signaling pathway through binding to the target, smoothened. PF-04449913 inhibits Hh signaling in vitro and has demonstrated significant antitumor activity in vivo. In the clinic, PF-04449913 ...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Sonidegib, also known as LDE225 and marketed as Odomzo, is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was approved by the FDA for treating basal cell carcinoma in July 2015 and ...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Vismodegib (trade name Erivedge) is a drug for the treatment of basal-cell carcinoma (BCC). It was approved by FDA on January 30, 2012 and by the European Commission on 12 July 2013, for the treatment of adult patients with symptomatic metastatic BCC...
FIN-6 (PATIDEGIB, IPI-926), a semisynthetic derivative of alkaloid cyclopamine, is a G protein-coupled receptor Smoothened (Smo) inhibitor with antineoplastic activity. Smo is a key signaling transmembrane protein in the Hedgehog signaling pathway wh...
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. Taladegib inhibits signaling that is mediated by the Hh pathway prote...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
BMS-833923 was discovered by Exelixis and was out-licensed to Bristol-Myers Squibb. BMS-833923 is an orally bioavailable Smoothened antagonist. BMS-833923 reduces hedgehog pathway activity, decreases cell proliferation and induces apoptosis via the i...
NPV-LEQ506 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. NPV-LEQ506 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh ...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
SANT-1 is antagonist of Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic development and can initiate or transmit ligand-independent pathway activation in tumorigenesis. It suppres...
Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Smoothened agonist (SAG), a chlorobenzothiophene-containing Hh pathway agonist, was shown to be able to bind directly to Smo and activate Shh-dependent pathway. SAG and similar compounds represent attractive molecules to be developed for treatment of...