Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H27N5 |
| Molecular Weight | 373.494 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=NN(C(C)=C1\C=N\N2CCN(CC3=CC=CC=C3)CC2)C4=CC=CC=C4
InChI
InChIKey=FOORCIAZMIWALX-JJIBRWJFSA-N
InChI=1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
| Molecular Formula | C23H27N5 |
| Molecular Weight | 373.494 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/19421011 | https://www.ncbi.nlm.nih.gov/pubmed/26943330 | https://www.ncbi.nlm.nih.gov/pubmed/26781311 | https://www.ncbi.nlm.nih.gov/pubmed/23548480
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/19421011 | https://www.ncbi.nlm.nih.gov/pubmed/26943330 | https://www.ncbi.nlm.nih.gov/pubmed/26781311 | https://www.ncbi.nlm.nih.gov/pubmed/23548480
SANT-1 is antagonist of Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic development and can initiate or transmit ligand-independent pathway activation in tumorigenesis. It suppressed cancer cell viability, proliferation and colony formation.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. | 2009 |
|
| Sonic hedgehog antagonists induce cell death in acute myeloid leukemia cells with the presence of lipopolysaccharides, tumor necrosis factor-α, or interferons. | 2013 Aug |
|
| Guggulsterone sensitizes glioblastoma cells to Sonic hedgehog inhibitor SANT-1 induced apoptosis in a Ras/NFκB dependent manner. | 2013 Aug 19 |
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| Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. | 2014 Jul 10 |
|
| Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines. | 2016 |
|
| Silibinin Treatment Inhibits the Growth of Hedgehog Inhibitor-Resistant Basal Cell Carcinoma Cells via Targeting EGFR-MAPK-Akt and Hedgehog Signaling. | 2017 Jul |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 20:02:25 GMT 2023
by
admin
on
Sat Dec 16 20:02:25 GMT 2023
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| Record UNII |
GYK6BKF2M2
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| Record Status |
Validated (UNII)
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| Record Version |
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GYK6BKF2M2
Created by
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304909-07-7
Created by
admin on Sat Dec 16 20:02:25 GMT 2023 , Edited by admin on Sat Dec 16 20:02:25 GMT 2023
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6878030
Created by
admin on Sat Dec 16 20:02:25 GMT 2023 , Edited by admin on Sat Dec 16 20:02:25 GMT 2023
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PRIMARY |