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Serum amyloid P-component

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Histamine H1 receptor

316

Dopamine D2 receptor

311

DNA

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Serotonin 2a (5-HT2a) receptor

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Miridesap

WO97N24A47

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Serum amyloid P-component

RO-638695 (also known as Miridesap, CPHPC and GSK-2315698) is an antineoplastic and a serum amyloid P component inhibitor. RO-638695 almost completely depletes circulating serum amyloid P component (SAP), but a small amount of SAP is left for recogni...

tion by subsequently administered therapeutic IgG anti-SAP antibodies. SAP is a blood protein that is the target of a novel immunotherapy approach. RO-638695 has therefore been evaluated in phase I and II clinical trials for its safety and potential in treatment of diseases like Alzheimer’s disease, HIV infection and other diseases with systemic amyloid deposition.

GSK-294

85VWJ67FZE

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Serum amyloid P-component

RO-638695 (also known as Miridesap, CPHPC and GSK-2315698) is an antineoplastic and a serum amyloid P component inhibitor. RO-638695 almost completely depletes circulating serum amyloid P component (SAP), but a small amount of SAP is left for recogni...

tion by subsequently administered therapeutic IgG anti-SAP antibodies. SAP is a blood protein that is the target of a novel immunotherapy approach. RO-638695 has therefore been evaluated in phase I and II clinical trials for its safety and potential in treatment of diseases like Alzheimer’s disease, HIV infection and other diseases with systemic amyloid deposition.

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