Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H24N2O6 |
| Molecular Weight | 340.3716 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)[C@H]1CCCN1C(=O)CCCCC(=O)N2CCC[C@@H]2C(O)=O
InChI
InChIKey=HZLAWYIBLZNRFZ-VXGBXAGGSA-N
InChI=1S/C16H24N2O6/c19-13(17-9-3-5-11(17)15(21)22)7-1-2-8-14(20)18-10-4-6-12(18)16(23)24/h11-12H,1-10H2,(H,21,22)(H,23,24)/t11-,12-/m1/s1
RO-638695 (also known as Miridesap, CPHPC and GSK-2315698) is an antineoplastic and a serum amyloid P component inhibitor. RO-638695 almost completely depletes circulating serum amyloid P component (SAP), but a small amount of SAP is left for recognition by subsequently administered therapeutic IgG anti-SAP antibodies. SAP is a blood protein that is the target of a novel immunotherapy approach. RO-638695 has therefore been evaluated in phase I and II clinical trials for its safety and potential in treatment of diseases like Alzheimer’s disease, HIV infection and other diseases with systemic amyloid deposition.
Originator
Approval Year
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C78275
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
|
||
|
FDA ORPHAN DRUG |
462614
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DB13087
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
|
PRIMARY | |||
|
DTXSID00176996
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
|
PRIMARY | |||
|
10363
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
|
PRIMARY | |||
|
100000174642
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
|
PRIMARY | |||
|
C153209
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
|
PRIMARY | |||
|
WO97N24A47
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
|
PRIMARY | |||
|
224624-80-0
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
|
PRIMARY | |||
|
CPHPC
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
|
PRIMARY | |||
|
125516
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
|
PRIMARY | |||
|
FG-82
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
