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Monoamine transporter

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316

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DNA

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Attention deficit hyperactivity disorder

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Exogenous obesity

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METHAMPHETAMINE SACCHARATE

K2J544L5HP

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Status:

US Approved Rx (1943)

First approved in 1943

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Trace amine-associated receptor 1

Adrenergic receptor alpha-2

Monoamine transporter

Synaptic vesicular amine transporter

Conditions:

Attention deficit hyperactivity disorder

Exogenous obesity

DL-Methamphetamine (also known as +/- Methamphetamin) is a central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal met...

h, ice, and speed. Methamphetamine is a mixture of two isomers. One isomer called Dextro, or D Methamphetamine, is active as a central nervous system stimulant and it is a DEA Schedule 2 controlled drug commonly called “Meth” or “Speed”. Desoxyn, a prescription drug also contains D Methamphetamine. The other isomer, Levo, or L Methamphetamine is not a DEA controlled drug. It is found in an over the counter medicine called “Vicks Inhaler” or as the prescription drug, Selegiline. (+)-methamphetamine is the more physiologically active isomer. In addition to some medications, L Methamphetamine can be produced in the illegal production of street Methamphetamine.

DASOTRALINE HYDROCHLORIDE

1VIY7J4C0I

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Norepinephrine transporter

Monoamine transporter

Dopamine transporter

Serotonin transporter

Sodium-dependent dopamine transporter

Sodium-dependent serotonin transporter

Sodium-dependent noradrenaline transporter

Conditions:

Binge eating disorder

Attention deficit hyperactivity disorder

Dasotraline, also known as SEP-225,289, is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It has an extended half-life (47-77 hours) that supports the potential for plasma concentrations yielding a continuous therapeutic effect over ...

the 24-hour dosing interval at steady state. Dasotraline has shown a lower potential for abuse than methylphenidate in clinical testing. Dasotraline was discovered by Sunovion Pharmaceuticals Inc. and is currently in development to evaluate its use in treating ADHD in adults and children, and BED in adults in the United States. It has not been approved by the U.S. Food and Drug Administration (FDA) for the treatment of ADHD, BED or any other disorder.

DIBENZEPIN

510SJZ1Y6L

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histamine H1 receptor

Monoamine transporter

Muscarinic acetylcholine receptor

Conditions:

Dibenzepin is a tricyclic antidepressant of the dibenzo-epine group. It is a selective noradrenaline uptake inhibitor, which exhibits in vitro and in vivo imipramine-like effects. It binds strongly to histamine H1 receptors in the brain and, to a les...

ser extent, to cholinergic receptors. The pharmacological profile of dibenzepin corresponds widely to its biochemical properties: histamine antagonism, tetrabenazine antagonism, potentiation of various noradrenergic effects and anticholinergic effects. Dibenzepin is only available in European countries for the treatment of depression.

METHAMPHETAMINE

44RAL3456C

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Status:

US Approved Rx (1943)

First approved in 1943

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Trace amine-associated receptor 1

Adrenergic receptor alpha-2

Monoamine transporter

Synaptic vesicular amine transporter

Conditions:

Attention deficit hyperactivity disorder

Exogenous obesity

DL-Methamphetamine (also known as +/- Methamphetamin) is a central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal met...

h, ice, and speed. Methamphetamine is a mixture of two isomers. One isomer called Dextro, or D Methamphetamine, is active as a central nervous system stimulant and it is a DEA Schedule 2 controlled drug commonly called “Meth” or “Speed”. Desoxyn, a prescription drug also contains D Methamphetamine. The other isomer, Levo, or L Methamphetamine is not a DEA controlled drug. It is found in an over the counter medicine called “Vicks Inhaler” or as the prescription drug, Selegiline. (+)-methamphetamine is the more physiologically active isomer. In addition to some medications, L Methamphetamine can be produced in the illegal production of street Methamphetamine.

METHAMPHETAMINE HYDROCHLORIDE, DL-

24GNZ56D62

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Status:

US Approved Rx (1943)

First approved in 1943

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Trace amine-associated receptor 1

Adrenergic receptor alpha-2

Monoamine transporter

Synaptic vesicular amine transporter

Conditions:

Attention deficit hyperactivity disorder

Exogenous obesity

DL-Methamphetamine (also known as +/- Methamphetamin) is a central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal met...

h, ice, and speed. Methamphetamine is a mixture of two isomers. One isomer called Dextro, or D Methamphetamine, is active as a central nervous system stimulant and it is a DEA Schedule 2 controlled drug commonly called “Meth” or “Speed”. Desoxyn, a prescription drug also contains D Methamphetamine. The other isomer, Levo, or L Methamphetamine is not a DEA controlled drug. It is found in an over the counter medicine called “Vicks Inhaler” or as the prescription drug, Selegiline. (+)-methamphetamine is the more physiologically active isomer. In addition to some medications, L Methamphetamine can be produced in the illegal production of street Methamphetamine.

METHAMPHETAMINE, DL-

13ZT6YG5SD

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Status:

US Approved Rx (1943)

First approved in 1943

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Trace amine-associated receptor 1

Adrenergic receptor alpha-2

Monoamine transporter

Synaptic vesicular amine transporter

Conditions:

Attention deficit hyperactivity disorder

Exogenous obesity

DL-Methamphetamine (also known as +/- Methamphetamin) is a central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal met...

h, ice, and speed. Methamphetamine is a mixture of two isomers. One isomer called Dextro, or D Methamphetamine, is active as a central nervous system stimulant and it is a DEA Schedule 2 controlled drug commonly called “Meth” or “Speed”. Desoxyn, a prescription drug also contains D Methamphetamine. The other isomer, Levo, or L Methamphetamine is not a DEA controlled drug. It is found in an over the counter medicine called “Vicks Inhaler” or as the prescription drug, Selegiline. (+)-methamphetamine is the more physiologically active isomer. In addition to some medications, L Methamphetamine can be produced in the illegal production of street Methamphetamine.

METHAMPHETAMINE TARTRATE

7520HJS99O

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Status:

US Approved Rx (1943)

First approved in 1943

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Trace amine-associated receptor 1

Adrenergic receptor alpha-2

Monoamine transporter

Synaptic vesicular amine transporter

Conditions:

Attention deficit hyperactivity disorder

Exogenous obesity

DL-Methamphetamine (also known as +/- Methamphetamin) is a central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal met...

h, ice, and speed. Methamphetamine is a mixture of two isomers. One isomer called Dextro, or D Methamphetamine, is active as a central nervous system stimulant and it is a DEA Schedule 2 controlled drug commonly called “Meth” or “Speed”. Desoxyn, a prescription drug also contains D Methamphetamine. The other isomer, Levo, or L Methamphetamine is not a DEA controlled drug. It is found in an over the counter medicine called “Vicks Inhaler” or as the prescription drug, Selegiline. (+)-methamphetamine is the more physiologically active isomer. In addition to some medications, L Methamphetamine can be produced in the illegal production of street Methamphetamine.

METHAMPHETAMINE HYDROCHLORIDE

997F43Z9CV

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Status:

US Approved Rx (1943)

First approved in 1943

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Trace amine-associated receptor 1

Adrenergic receptor alpha-2

Monoamine transporter

Synaptic vesicular amine transporter

Conditions:

Attention deficit hyperactivity disorder

Exogenous obesity

DL-Methamphetamine (also known as +/- Methamphetamin) is a central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal met...

h, ice, and speed. Methamphetamine is a mixture of two isomers. One isomer called Dextro, or D Methamphetamine, is active as a central nervous system stimulant and it is a DEA Schedule 2 controlled drug commonly called “Meth” or “Speed”. Desoxyn, a prescription drug also contains D Methamphetamine. The other isomer, Levo, or L Methamphetamine is not a DEA controlled drug. It is found in an over the counter medicine called “Vicks Inhaler” or as the prescription drug, Selegiline. (+)-methamphetamine is the more physiologically active isomer. In addition to some medications, L Methamphetamine can be produced in the illegal production of street Methamphetamine.

DASOTRALINE

4D28EY0L5T

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Norepinephrine transporter

Monoamine transporter

Dopamine transporter

Serotonin transporter

Sodium-dependent dopamine transporter

Sodium-dependent serotonin transporter

Sodium-dependent noradrenaline transporter

Conditions:

Binge eating disorder

Attention deficit hyperactivity disorder

Dasotraline, also known as SEP-225,289, is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It has an extended half-life (47-77 hours) that supports the potential for plasma concentrations yielding a continuous therapeutic effect over ...

the 24-hour dosing interval at steady state. Dasotraline has shown a lower potential for abuse than methylphenidate in clinical testing. Dasotraline was discovered by Sunovion Pharmaceuticals Inc. and is currently in development to evaluate its use in treating ADHD in adults and children, and BED in adults in the United States. It has not been approved by the U.S. Food and Drug Administration (FDA) for the treatment of ADHD, BED or any other disorder.

DIBENZEPIN HYDROCHLORIDE

JLN0273S4Z

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histamine H1 receptor

Monoamine transporter

Muscarinic acetylcholine receptor

Conditions:

Dibenzepin is a tricyclic antidepressant of the dibenzo-epine group. It is a selective noradrenaline uptake inhibitor, which exhibits in vitro and in vivo imipramine-like effects. It binds strongly to histamine H1 receptors in the brain and, to a les...

ser extent, to cholinergic receptors. The pharmacological profile of dibenzepin corresponds widely to its biochemical properties: histamine antagonism, tetrabenazine antagonism, potentiation of various noradrenergic effects and anticholinergic effects. Dibenzepin is only available in European countries for the treatment of depression.

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