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Details

Stereochemistry ACHIRAL
Molecular Formula C18H21N3O
Molecular Weight 295.3795
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIBENZEPIN

SMILES

CN(C)CCN1c2ccccc2N(C)c3ccccc3C1=O

InChI

InChIKey=QPGGEKPRGVJKQB-UHFFFAOYSA-N
InChI=1S/C18H21N3O/c1-19(2)12-13-21-17-11-7-6-10-16(17)20(3)15-9-5-4-8-14(15)18(21)22/h4-11H,12-13H2,1-3H3

HIDE SMILES / InChI

Description
Curator's Comment:: Description was created based on several sources, including http://mentalhealthdaily.com/2014/08/18/tricyclic-antidepressants-list-tcas/

Dibenzepin is a tricyclic antidepressant of the dibenzo-epine group. It is a selective noradrenaline uptake inhibitor, which exhibits in vitro and in vivo imipramine-like effects. It binds strongly to histamine H1 receptors in the brain and, to a lesser extent, to cholinergic receptors. The pharmacological profile of dibenzepin corresponds widely to its biochemical properties: histamine antagonism, tetrabenazine antagonism, potentiation of various noradrenergic effects and anticholinergic effects. Dibenzepin is only available in European countries for the treatment of depression.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
NOVERIL

Approved Use

Noveril (dibenzepin) is indicated for the treatment of depression
PubMed

PubMed

TitleDatePubMed
Therapeutic drug monitoring of 13 antidepressant and five neuroleptic drugs in serum with liquid chromatography-electrospray ionization mass spectrometry.
2003 Dec
Comparison of trazodone, diazepame and dibenzepine influences on rat brain beta-endorphins content.
2007 Aug
Inhibition of the cardiac L-type calcium channel current by antidepressant drugs.
2008 Mar
Tricyclic antidepressants and headaches: systematic review and meta-analysis.
2010 Oct 20
Patents

Sample Use Guides

In adult patients, treatment should begin with Noveril (dibenzepin) 240 mg tablets, the daily dose being given as a single dose or in 2 divided dose.
Route of Administration: Oral
Dibenzepin blocked calcium current in enzymatically isolated rat ventricular myocytes with IC(50) values of 364 uM.
Name Type Language
DIBENZEPIN
INN   MI   WHO-DD  
INN  
Official Name English
10-(2-(DIMETHYLAMINO)ETHYL)-5,10-DIHYDRO-5-METHYL-11-H-DIBENZO(B,E)(1,4)DIAZEPIN-11-ONE
Common Name English
DIBENZEPINE
Common Name English
DIBENZEPIN [WHO-DD]
Common Name English
DIBENZEPIN [MI]
Common Name English
DIBENZEPIN [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QN06AA08
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
WHO-ATC N06AA08
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
Code System Code Type Description
EPA CompTox
4498-32-2
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY
PUBCHEM
9419
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY
INN
1738
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY
CAS
4498-32-2
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY
WIKIPEDIA
Dibenzepin
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY
MESH
C084605
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY
DRUG CENTRAL
856
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY
NCI_THESAURUS
C166799
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY
EVMPD
SUB07074MIG
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY
RXCUI
3332
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY RxNorm
MERCK INDEX
M4282
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY Merck Index
ChEMBL
CHEMBL1442422
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY
DRUG BANK
DB13225
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY
FDA UNII
510SJZ1Y6L
Created by admin on Sat Jun 26 04:49:11 UTC 2021 , Edited by admin on Sat Jun 26 04:49:11 UTC 2021
PRIMARY