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Details

Stereochemistry ACHIRAL
Molecular Formula C18H21N3O
Molecular Weight 295.3788
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIBENZEPIN

SMILES

CN(C)CCN1C2=C(C=CC=C2)N(C)C3=C(C=CC=C3)C1=O

InChI

InChIKey=QPGGEKPRGVJKQB-UHFFFAOYSA-N
InChI=1S/C18H21N3O/c1-19(2)12-13-21-17-11-7-6-10-16(17)20(3)15-9-5-4-8-14(15)18(21)22/h4-11H,12-13H2,1-3H3

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including http://mentalhealthdaily.com/2014/08/18/tricyclic-antidepressants-list-tcas/

Dibenzepin is a tricyclic antidepressant of the dibenzo-epine group. It is a selective noradrenaline uptake inhibitor, which exhibits in vitro and in vivo imipramine-like effects. It binds strongly to histamine H1 receptors in the brain and, to a lesser extent, to cholinergic receptors. The pharmacological profile of dibenzepin corresponds widely to its biochemical properties: histamine antagonism, tetrabenazine antagonism, potentiation of various noradrenergic effects and anticholinergic effects. Dibenzepin is only available in European countries for the treatment of depression.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
NOVERIL

Approved Use

Noveril (dibenzepin) is indicated for the treatment of depression
PubMed

PubMed

TitleDatePubMed
Dibenzepin and amitriptyline in the treatment of depression.
1971 May
Drug-induced rapid cycling: possible outcomes and management.
1982 Jul
Direct-injection high performance liquid chromatography ion trap mass spectrometry for the quantitative determination of olanzapine, clozapine and N-desmethylclozapine in human plasma.
2002
Simultaneous determination of seven tricyclic antidepressant drugs in human plasma by direct-injection HPLC-APCI-MS-MS with an ion trap detector.
2002 Aug
Discrimination in 5-HT(3) receptor binding in murine brain and cultured cell preparations.
2002 Feb
Therapeutic drug monitoring of 13 antidepressant and five neuroleptic drugs in serum with liquid chromatography-electrospray ionization mass spectrometry.
2003 Dec
Precise gas chromatography with retention time locking in comprehensive toxicological screening for drugs in blood.
2003 May 25
Comparison of trazodone, diazepame and dibenzepine influences on rat brain beta-endorphins content.
2007 Aug
Inhibition of the cardiac L-type calcium channel current by antidepressant drugs.
2008 Mar
Tricyclic antidepressants and headaches: systematic review and meta-analysis.
2010 Oct 20
Patents

Sample Use Guides

In adult patients, treatment should begin with Noveril (dibenzepin) 240 mg tablets, the daily dose being given as a single dose or in 2 divided dose.
Route of Administration: Oral
Dibenzepin blocked calcium current in enzymatically isolated rat ventricular myocytes with IC(50) values of 364 uM.
Name Type Language
DIBENZEPIN
INN   MI   WHO-DD  
INN  
Official Name English
10-(2-(DIMETHYLAMINO)ETHYL)-5,10-DIHYDRO-5-METHYL-11-H-DIBENZO(B,E)(1,4)DIAZEPIN-11-ONE
Common Name English
DIBENZEPINE
Common Name English
Dibenzepin [WHO-DD]
Common Name English
DIBENZEPIN [MI]
Common Name English
dibenzepin [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QN06AA08
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
WHO-ATC N06AA08
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
Code System Code Type Description
EPA CompTox
DTXSID7022916
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
PRIMARY
PUBCHEM
9419
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
PRIMARY
INN
1738
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
PRIMARY
SMS_ID
100000082888
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
PRIMARY
CAS
4498-32-2
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
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WIKIPEDIA
Dibenzepin
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
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MESH
C084605
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
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DRUG CENTRAL
856
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
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NCI_THESAURUS
C166799
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
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EVMPD
SUB07074MIG
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
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RXCUI
3332
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
PRIMARY RxNorm
MERCK INDEX
m4282
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
PRIMARY Merck Index
ChEMBL
CHEMBL1442422
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
PRIMARY
DRUG BANK
DB13225
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
PRIMARY
FDA UNII
510SJZ1Y6L
Created by admin on Fri Dec 15 17:36:07 UTC 2023 , Edited by admin on Fri Dec 15 17:36:07 UTC 2023
PRIMARY