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Showing 1 - 10 of 75 results

Status:
US Approved Rx (2023)
First approved in 2023

Class (Stereo):
CHEMICAL (ABSOLUTE)


Elacestrant (ER-306323 or RAD 1901 [6R)-6-(2-(N-(4-(2-(ethylamino)ethyl)benzyl)-N-ethylamino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol dihydrochloride]) is a selective estrogen receptor (ER) degrader. Elacestrant induces the degradation of ...
Status:
US Approved Rx (2024)
First approved in 2013

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Ospemifene (commercial name Osphena produced by Shionogi) is anoral medication indicated for the treatment of dyspareunia – pain during sexual intercourse – encountered by some women, more often in those who are post-menopausal. Ospemifene ...
Status:
US Approved Rx (2013)
First approved in 2013

Class (Stereo):
CHEMICAL (ACHIRAL)



Bazedoxifene acetate (WAY-140424; TSE-424) is an oral, nonsteroidal, indole-based selective estrogen-receptor modulator developed by Ligand Pharmaceuticals in collaboration with Wyeth Pharmaceuticals (NJ, USA) (now Pfizer) . It was developed using ra...
Status:
US Approved Rx (2016)
First approved in 1997

Class (Stereo):
CHEMICAL (ACHIRAL)



Raloxifene (marketed as Evista by Eli Lilly and Company) is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. Raloxifene binds to estrogen receptors, resulti...
Status:
US Approved Rx (2005)
First approved in 1977

Class (Stereo):
CHEMICAL (ACHIRAL)



Tamoxifen (brand name Nolvadex), is selective estrogen receptor modulators (SERM) with tissue-specific activities for the treatment and prevention of estrogen receptor positive breast cancer. Tamoxifen itself is a prodrug, having relatively little af...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)



Enclomiphene (Androxal), in development by Repros Therapeutics Inc, is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. Enclomiphene constitutes the trans-stereoisomer of clomiphe...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)


Nylestriol is a synthetic estrogen which is marketed in China under the brand name Wei Ni An. Nylestriol can be used as an effective and acceptable estrogen replacement therapy for postmenopausal women. It was found to be effective, safe and conveni...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)



Juvantia Pharma and Orion developed ORM-12741, also known as ORM-10921, a novel selective antagonist of alpha-2C adrenoceptors for the treatment of depression and Alzheimer's disease. ORM-12741 participated in phase II clinical trial where was evalua...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)



(E)-Endoxifen is the E-isomer of (Z)-Endoxifen, potent selective estrogen receptor modulator. Endoxifen exists as the potently anti-estrogenic (Z)-isomer and the lesser known (E)-isomer. It is assumed that (E)-Endoxifen, structurally related to (E)-4...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Etocrylene is an organic ester that appears as an off-white crystalline powder and functions as a UV absorber. When applied to the skin, this product absorbs UV rays. It can also be used to protect cosmetics and personal care products from deteriorat...