Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Sodium thiosulfate (sodium thiosulphate/STS) is a chemical and medication. As a medication, it is used in combination with sodium nitrite under the trade name to NITHIODOTE treat cyanide poisoning. The primary route of endogenous cyanide detoxificati...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Procaspase-activating compound 1, PAC-1, has been introduced as a direct activator of procaspase-3 and has been suggested as a therapeutic agent against cancer. Its activation of procaspase-3 is dependent on the chelation of zinc. In 2015, a phase I ...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor. Aloxistatin was developed for treating muscular dystrophy. Open trials on 73 Duchene’s muscular dystrophy patients were conducted for 3 years at four Japanese n...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Naringin is a flavanone plant metabolite which found in citrus fruits and in quantitatively significant amounts from grapefruit in particular. Naringin has attracted attention as a dietary supplement purported to aid in fat and weight loss. Ingesti...
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Levistolide A is a naturally occurring compound isolated from Ligusticum chuanxiong Hort, which is used in traditional Chinese medicine to treat cancer. Levistolide has been studied in vitro against cell models for colon cancer and breast cancer. I...
Status:
Other
Class (Stereo):
CHEMICAL (EPIMERIC)
Targets:
MDL-201053, (DL-ALANINE)- (Z-FA-FMK) is an irreversible inhibitor of cysteine proteases, such as cathepsin B, L, and S. The compound has also inhibitited papain and cruzain. Z-FA-FMK has been shown to selectively inhibit effector caspase-2, caspase-3...
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Aflatoxin G1 ((7aR,10aS)-3,4,7a,10a-tetrahydro-5-methoxy-1H,12H-furo[3',2':4,5]furo[2,3-h]pyrano[3,4-c][1]benzopyran-1,12-dione) is a food contaminant produced by various species of the common soil fungus, Aspergillus and is associated with toxicity ...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Esculetin (aka Aesculetin) is a derivative of coumarin. It is a naturally occurring lactone which is present in chicory and in many toxic medicinal plants; often found in a glycosidic form or conjugated to caffeic acids. It is used as an ingredient i...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Tangeretin is an O-polymethoxylated flavone that is found in tangerine and other citrus peels. Its natural role is to strengthen the cell wall and act as a plant's defensive mechanism against disease-causing pathogens. Animal studies have shown the p...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Beta-sitosterol is one of the main dietary phytosterols found in plants which have a similar skeleton as cholesterol. In human clinical trials, beta-sitosterol has been shown to have cholesterol-lowering effects and to relieve symptoms of benign pro...