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Details

Stereochemistry ACHIRAL
Molecular Formula O3S2
Molecular Weight 112.128
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -2

SHOW SMILES / InChI
Structure of THIOSULFATE ION

SMILES

[O-]S([S-])(=O)=O

InChI

InChIKey=DHCDFWKWKRSZHF-UHFFFAOYSA-L
InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2

HIDE SMILES / InChI
Sodium thiosulfate (sodium thiosulphate/STS) is a chemical and medication. As a medication, it is used in combination with sodium nitrite under the trade name to NITHIODOTE treat cyanide poisoning. The primary route of endogenous cyanide detoxification is by enzymatic transulfuration to thiocyanate (SCN- ), which is relatively nontoxic and readily excreted in the urine. Sodium thiosulfate is thought to serve as a sulfur donor in the reaction catalyzed by the enzyme rhodanese, thus enhancing the endogenous detoxification of cyanide. In addition, Sodium thiosulfate is used in calciphylaxis in hemodialysis patients with end-stage kidney disease. Calciphylaxis is vasculopathy characterized by ischemia and painful skin necrosis due to calcification and intimal fibroplasia of thrombosis of the panicular arterioles. Sodium thiosulfate is used as treatment due to its antioxidant activity and as a chelating. Sodium thiosulfate renders renal protection by modulating the mitochondrial KATP channel for preventing urolithiasis. Moreover, STS was assumed to play a vital role in on ischemia reperfusion injury (IR). The effectiveness of STS as a cardioprotective agent was attributed to the reduction of apoptosis by binding to the active site of caspase-3 in silico, which was substantiated by the reduced expression of caspase-3 and poly ADP ribose polymerase levels.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P42574
Gene ID: 836.0
Gene Symbol: CASP3
Target Organism: Homo sapiens (Human)
Target ID: Q15842
Gene ID: 3764.0
Gene Symbol: KCNJ8
Target Organism: Homo sapiens (Human)
Target ID: Q14654
Gene ID: 3767.0
Gene Symbol: KCNJ11
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
NITHIODOTE

Approved Use

Sodium nitrite and sodium thiosulfate are indicated for sequential use for treatment of acute cyanide poisoning that is judged to be lifethreatening. Use with caution if the diagnosis of cyanide poisoning is uncertain.

Launch Date

2011
Palliative
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Sucrose teepol tellurite agar: a new selective indicator medium for isolation of Vibrio species.
1977 Apr
Determination of thiosulfate in body fluids by GC and GC/MS.
1991 May-Jun
The utilization of thiocyanate as a nitrogen source by a heterotrophic bacterium: the degradative pathway involves formation of ammonia and tetrathionate.
1994 Oct
Bactericidal activities of povidone-iodine against Mycobacterium.
1997
Bactericidal activities of commonly used antiseptics against multidrug-resistant mycobacterium tuberculosis.
2002
Patents

Sample Use Guides

acute cyanide intoxication: Adults: 1.) Sodium Nitrite -10 mL of a 3% solution (300 mg) of sodium nitrite at the rate of 2.5 to 5 mL/minute 2.) Sodium Thiosulfate - 50 mL of a 25% solution (12.5 g) of a sodium thiosulfate solution immediately following administration of sodium nitrite. Children: 1.) Sodium Nitrite -0.2 mL/kg of a 3% solution (6 mg/kg or 6-8 mL/m2 BSA) of sodium nitrite at the rate of 2.5 to 5 mL/minute not to exceed 10 mL (300 mg) 2.) Sodium Thiosulfate - 1 mL/kg of body weight using a 25% solution (250 mg/kg or approximately 30-40 mL/m2 of BSA) not to exceed 50 mL (12.5 g) total dose immediately following administration of sodium nitrite.
Route of Administration: Intravenous
There were investigated the effectiveness of Sodium thiosulfate (STS) as a cardioprotective agent is attributed to the reduction of apoptosis by binding to the active site of caspase-3 in silico, which was substantiated by the reduced expression of caspase-3 and poly ADP ribose polymerase levels. STS of 1 mM recovered H9C2 cells from glucose oxidase/catalase-induced apoptosis. The isolated rat heart treated with STS prior to reperfusion injury (IR) injury improved its hemodynamics and reduced the infarct size to 9%. An in silico docking analysis revealed higher binding affinity of STS for caspase-3 with a binding energy of - 60.523 kcal/mol for the complex.
Name Type Language
THIOSULFATE ION
Common Name English
THIOSULFATE ION(2-)
Common Name English
THIOSULPHATE ION
Common Name English
THIOSULPHATE (S2O32-)
Common Name English
THIOSULFATE (S2O32-)
Common Name English
THIOSULPHATE ION(2-)
Common Name English
Code System Code Type Description
PUBCHEM
1084
Created by admin on Fri Dec 15 18:55:06 GMT 2023 , Edited by admin on Fri Dec 15 18:55:06 GMT 2023
PRIMARY
EPA CompTox
DTXSID80932118
Created by admin on Fri Dec 15 18:55:06 GMT 2023 , Edited by admin on Fri Dec 15 18:55:06 GMT 2023
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WIKIPEDIA
Thiosulfate
Created by admin on Fri Dec 15 18:55:06 GMT 2023 , Edited by admin on Fri Dec 15 18:55:06 GMT 2023
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DAILYMED
LLT6XV39PY
Created by admin on Fri Dec 15 18:55:06 GMT 2023 , Edited by admin on Fri Dec 15 18:55:06 GMT 2023
PRIMARY
CAS
14383-50-7
Created by admin on Fri Dec 15 18:55:06 GMT 2023 , Edited by admin on Fri Dec 15 18:55:06 GMT 2023
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FDA UNII
LLT6XV39PY
Created by admin on Fri Dec 15 18:55:06 GMT 2023 , Edited by admin on Fri Dec 15 18:55:06 GMT 2023
PRIMARY
RXCUI
1546411
Created by admin on Fri Dec 15 18:55:06 GMT 2023 , Edited by admin on Fri Dec 15 18:55:06 GMT 2023
PRIMARY RxNorm
CHEBI
16094
Created by admin on Fri Dec 15 18:55:06 GMT 2023 , Edited by admin on Fri Dec 15 18:55:06 GMT 2023
PRIMARY