UNBS5162 is a naphthalimide that binds to DNA by intercalation and suppresses CXCL chemokine elaboration. In vivo and in vitro studies demonstrated potent antineoplastic properties of the compound. The phase 1 dose-escalation trial demonstrated that despite pre-clinical data suggesting low risk of QTc prolongation with UNBS5162 administration, there was a statistically significant relationship noted in study patients. The magnitude of QTc prolongation at the highest doses warranted the study drug to be terminated.

4-Hydroxy-N-methyl-N-ethyltryptamine (4-HO-MET) is a new psychoactive substance (NPS) of the chemical class of tryptamines. It shows structural similarities to the endogenous neurotransmitter serotonin, and is a serotonergic hallucinogen, affecting emotional, motoric, and cognitive functions. It is a structural and functional analog of psilocin as well as the 4-hydroxy analog of MET. 4-HO-MET was first synthesized by Alexander Shulgin. The effects of 4-HO-MET are quite comparable to the effects of psyloc(yb)in, which should be no surprise considering the structural similarities between these compounds. As with other hallucinogens, alterations of color, time, music have been reported (synesthesia). Extensive time dilatation has been reported. The overall effects have been reported to be very comparable to those of psiloc(yb)in. Comparable to psilocin, the mental health risks include fear, anxiety and paranoia. Treatment of intoxication is symptomatic: calming the patient, transferring to a non-discomforting room. In severe cases an anxiolytic (diazepam, alprazolam) can be used. Antidote: The hallucinogenic effects can be totally reversed by administration of a 5-HT2A antagonist, such as Zyprexa.

The DOTAP (N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate) is a liposomal transfection reagent suitable for transient and stable transfection of mammalian cell lines with DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides). Mixing DOTAP with DNA results in spontaneously formed stable complexes. These complexes can be added directly to the tissue culture medium. This method avoiding the cytotoxic effects commonly encountered with lipofection or others transfection methods. The recently published article described the ability of R-DOTAP stabilized microparticles (MP) to act as a carrier platform for antigens e.g. for cancer vaccination. It was investigated whether or not a combination of R-DOTAP and PLGA leads to a boosted adjuvant effect in dendritic cell maturation.