GYKI-472611 is a non-competitive AMPA antagonist receptor. Also, GYKI-47261 was considered as a potent CYP2E1 inducer. In vivo, it displays broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-472611 developed by IVAX Drug Research Institute Ltd. for treatment of epilepsy and parkinsonism.

WAY 267464 dihydrochloride is a potent and selective agonist at the oxytocin receptor (OTR). WAY 267464 has been shown to cross the blood-brain-barrier to a significantly greater extent than exogenously applied oxytocin. WAY 267464 dose-dependently reduced anxiety on the four-plate test and prevented the deficits in prepulse inhibition induced by MK-801 or amphetamine. The ability of WAY 267464 to function as a V1AR antagonist may limit its potential therapeutic use in humans, as it would conceivably prevent the improvements in social behavior and social cognition that may be assumed to arise from a primary OTR agonist action.

N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulphonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA) is a high-affinity, reversible and selective orexin type 2 (OX2) receptor antagonist. The in vivo activity of EMPA was assessed by reversal of orexin-B-induced hyperlocomotion during the resting phase in mice and the reduction of spontaneous locomotor activity (LMA) during the active phase in rats.