AM-0902

CN1C=NC2=C1C(=O)N(CC3=NC(CCC4=CC=C(Cl)C=C4)=NO3)C=N2

InChIKey=AWJBWNUUODWOKQ-UHFFFAOYSA-N

InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Transient receptor potential cation channel subfamily A member 1 38 Target ID: CHEMBL6007 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26942860	Antagonist 2778		131.0 nM [IC50]

PubMed

Title	Date	PubMed
Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity.	2016 Mar 24	26942860
Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain.	2019 May	30716174

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:16:36 UTC 2023` Edited by `admin` on `Sat Dec 16 18:16:36 UTC 2023`
Record UNII	3E4SQ96PCJ
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

AM-0902

Code

English

6H-PURIN-6-ONE, 1-((3-(2-(4-CHLOROPHENYL)ETHYL)-1,2,4-OXADIAZOL-5-YL)METHYL)-1,7-DIHYDRO-7-METHYL-

Systematic Name

English

AMG-0902

Code

English

1-((3-(2-(4-CHLOROPHENYL)ETHYL)-1,2,4-OXADIAZOL-5-YL)METHYL)-1,7-DIHYDRO-7-METHYL-6H-PURIN-6-ONE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID101336572