Inxight Drugs

Showing 1 - 10 of 22 results

Status:

US Approved Rx (2017)

First marketed in 1937

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Testosterone is a steroid sex hormone found in both men and women. In men, testosterone is produced primarily by the Leydig (interstitial) cells of the testes when stimulated by luteinizing hormone (LH). It functions to stimulate spermatogenesis, pro...

mote physical and functional maturation of spermatozoa, maintain accessory organs of the male reproductive tract, support development of secondary sexual characteristics, stimulate growth and metabolism throughout the body and influence brain development by stimulating sexual behaviors and sexual drive. In women, testosterone is produced by the ovaries (25%), adrenals (25%) and via peripheral conversion from androstenedione (50%). Testerone in women functions to maintain libido and general wellbeing. Testosterone exerts a negative feedback mechanism on pituitary release of LH and follicle-stimulating hormone (FSH). Testosterone may be further converted to dihydrotestosterone or estradiol depending on the tissue. The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects. Testosterone is used as hormone replacement or substitution of diminished or absent endogenous testosterone. Use in males: For management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Use in females: For palliative treatment of androgen-responsive, advanced, inoperable, metastatis (skeletal) carcinoma of the breast in women who are 1-5 years postmenopausal; testosterone esters may be used in combination with estrogens in the management of moderate to severe vasomotor symptoms associated with menopause in women who do not respond to adequately to estrogen therapy alone.

CLOMIPHENE

MORE DETAILS

1HRS458QU2

Status:

US Approved Rx (2017)

First marketed in 1937

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Development Status

Primary Target

Highest Phase

Approval Year

Condition

Treatment Modality

CNS Activity

Originator

Substance Class

Code System

ATC Level 1

ATC Level 2

ATC Level 3

ATC Level 4

Substance Form

TESTOSTERONE

3XMK78S47O

CLOMIPHENE

1HRS458QU2

ZUCLOMIPHENE

3JU1DU3652

TESTOSTERONE DODECANOATE

OE4Q4W32JK

TESTOSTERONE CYCLOHEXYL PROPIONATE

930D2884KV

TESTOSTERONE HEXYLOXYPHENYL PROPIONATE

18BZ96H4K3

TESTOSTERONE TRIDECANOATE

33T917L157

TESTOSTERONE CYCLOHEXANOATE

T4QOX8847Z

TESTOSTERONE UNDECANOATE

H16A5VCT9C

TESTOSTERONE ENANTATE BENZILIC ACID HYDRAZONE

X8Z8A2G2Y4