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US Approved Allergenic Extract

2

US Previously Marketed

1

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Primary Target

Candida

2

HMG-CoA reductase

2

Trichomonas vaginalis

2

Acetylcholinesterase

1

Alpha-glucosidase MAL62

1

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Highest Phase

Phase III

2

Phase I

1

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Approval Year

1921

1

1994

2

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Condition

Cancer

2

Candida infections

2

Hyperlipidemia

2

Pain

2

Trichomoniasis

2

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Treatment Modality

Primary

3

Curative

2

Palliative

1

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CNS Activity

CNS Active

1

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Originator

Gobley, N.-T.

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Substance Class

Chemical

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Code System

CAS

3

CHEBI

3

DAILYMED

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ECHA (EC/EINECS)

3

EPA CompTox

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Substance Form

Principal Form

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Salts, Hydrates, Esters, etc.

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GERANIOL

L837108USY

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Status:

US Approved Allergenic Extract (1994)

First approved in 1994

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Trichomonas vaginalis

HMG-CoA reductase

Conditions:

Uterine cervical dysplasia

Candida infections

Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic plants. To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, pro...

state, pancreatic, and hepatic cancer, and has revealed the mechanistic basis for its pharmacological actions. In addition, geraniol sensitizes tumor cells to commonly used chemotherapy agents. Geraniol controls a variety of signaling molecules and pathways that represent tumor hallmarks; these actions of geraniol constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs. It has been shown that geraniol inhibits HMG-CoA reductase in most types of tumor cells, which raises the possibility that the reduced prenylation of small G-proteins, such as Ras or RhoA, accounts for the antitumor effects of geraniol. In addition to its use in various commercial products, including cosmetics and fine fragrances, geraniol exerts a broad spectrum of pharmacological activities, such as anti-microbial, anti-inflammatory, anti-oxidant, anti-ulcer and neuroprotective activities. Geraniol is classified into the generally recognized-as-safe (GRAS) category by the Flavor and Extract Manufacturers Association (FEMA) and the Food and Drug Administration (FDA) of the United States.

Vanillin

CHI530446X

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Alpha-glucosidase MAL62

Transient receptor potential cation channel subfamily V member 1

Acetylcholinesterase

Oxidative Stress

Conditions:

Parkinson's disease

Premature newborns

Alzheimer’s disease

Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed anti...

oxidant and neuroprotective activities. Vanillin is a natural substance widely found in many plant species and often used in beverages, foods, cosmetics, and pharmaceutical products. Antioxidant and anticancer potential have been described for this compound. Vanillin has been classified as a bioantimutagen and is able to inhibit mutagenesis induced by chemical and physical mutagens in various cell systems. Vanillin, a selective agonist of TRPV1, has been shown to attenuate i.c.v. STZ and AlCl3+d-galactose induced experimental Alzheime's disease (AD).

NEROL

38G5P53250

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Status:

US Approved Allergenic Extract (1994)

First approved in 1994

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Trichomonas vaginalis

HMG-CoA reductase

Conditions:

Uterine cervical dysplasia

Candida infections

Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic plants. To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, pro...

state, pancreatic, and hepatic cancer, and has revealed the mechanistic basis for its pharmacological actions. In addition, geraniol sensitizes tumor cells to commonly used chemotherapy agents. Geraniol controls a variety of signaling molecules and pathways that represent tumor hallmarks; these actions of geraniol constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs. It has been shown that geraniol inhibits HMG-CoA reductase in most types of tumor cells, which raises the possibility that the reduced prenylation of small G-proteins, such as Ras or RhoA, accounts for the antitumor effects of geraniol. In addition to its use in various commercial products, including cosmetics and fine fragrances, geraniol exerts a broad spectrum of pharmacological activities, such as anti-microbial, anti-inflammatory, anti-oxidant, anti-ulcer and neuroprotective activities. Geraniol is classified into the generally recognized-as-safe (GRAS) category by the Flavor and Extract Manufacturers Association (FEMA) and the Food and Drug Administration (FDA) of the United States.

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