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Possibly Marketed Outside US

4

US Approved Rx

4

Other

2

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Primary Target

Cyclooxygenase-2

4

GO:0004144 diacylglycerol O-acyltransferase activity

4

GO:0004465 lipoprotein lipase activity

4

NF-kappa B signaling pathway

4

Peroxisome proliferator-activated receptor delta

4

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Highest Phase

Approved

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Approval Year

2007

4

2008

4

Unknown

2

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Condition

Alzheimer’s disease

8

Age-related macular degeneration

4

Coronary heart disease

4

Hypertriglyceridemia

4

Major depressive disorder

4

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Treatment Modality

Primary

8

Palliative

4

Preventing

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CNS Activity

CNS Active

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Originator

Farmer, E.H.|Van Den Heuvel, F.A.

4

Scarista

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Chemical

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CAS

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FDA UNII

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PUBCHEM

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EPA CompTox

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SMS_ID

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Salts, Hydrates, Esters, etc.

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Showing 1 - 10 of 10 results

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ICOSAPENT

AAN7QOV9EA

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Status:

US Approved Rx (2023)

First approved in 2008

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

fatty acid beta-oxidation

GO:0004465 lipoprotein lipase activity

GO:0004144 diacylglycerol O-acyltransferase activity

Peroxisome proliferator-activated receptor gamma

lipoprotein oxidation

transformed cell apoptotic process

Receptor-mediated non-selective cation current (Icat)

Peroxisome proliferator-activated receptor delta

Prolyl endopeptidase

Cyclooxygenase-2

Conditions:

Hypertriglyceridemia

Major depressive disorder

Alzheimer’s disease

Icosapent is an important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardio...

vascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families. EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.

2,4,6,8,10-EICOSAPENTAENOIC ACID, (2E,4E,6E,8E,10E)-

NT3H35FB86

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

CLUPANODONIC ACID

NS3OZT14QT

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

DOCONEXENT

ZAD9OKH9JC

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Status:

Possibly Marketed Outside US

First approved in 2007

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NF-kappa B signaling pathway

Voltage-gated L-type calcium channel

fatty acid metabolic process

Conditions:

Alzheimer’s disease

Coronary heart disease

Age-related macular degeneration

Doconexent (Docosahexaenoic acid, DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. DHA is widely used as a food supplement, and is beleived to support healthy brain developmen...

t in young childred, prevent cardiovascular disease and cognitive decline during Alzheimer's disease. Most of these claims, however, were not supported by clinical trials. DHA spray is used as a tanner.

Icosapent lysine salt

XX8KWN4FNB

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Status:

US Approved Rx (2023)

First approved in 2008

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

fatty acid beta-oxidation

GO:0004465 lipoprotein lipase activity

GO:0004144 diacylglycerol O-acyltransferase activity

Peroxisome proliferator-activated receptor gamma

lipoprotein oxidation

transformed cell apoptotic process

Receptor-mediated non-selective cation current (Icat)

Peroxisome proliferator-activated receptor delta

Prolyl endopeptidase

Cyclooxygenase-2

Conditions:

Hypertriglyceridemia

Major depressive disorder

Alzheimer’s disease

Icosapent is an important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardio...

vascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families. EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.

ICOSAPENT SODIUM

5PXN91KPRO

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Status:

US Approved Rx (2023)

First approved in 2008

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

fatty acid beta-oxidation

GO:0004465 lipoprotein lipase activity

GO:0004144 diacylglycerol O-acyltransferase activity

Peroxisome proliferator-activated receptor gamma

lipoprotein oxidation

transformed cell apoptotic process

Receptor-mediated non-selective cation current (Icat)

Peroxisome proliferator-activated receptor delta

Prolyl endopeptidase

Cyclooxygenase-2

Conditions:

Hypertriglyceridemia

Major depressive disorder

Alzheimer’s disease

Icosapent is an important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardio...

vascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families. EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.

ICOSAPENT ETHYL

6GC8A4PAYH

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Status:

US Approved Rx (2023)

First approved in 2008

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

fatty acid beta-oxidation

GO:0004465 lipoprotein lipase activity

GO:0004144 diacylglycerol O-acyltransferase activity

Peroxisome proliferator-activated receptor gamma

lipoprotein oxidation

transformed cell apoptotic process

Receptor-mediated non-selective cation current (Icat)

Peroxisome proliferator-activated receptor delta

Prolyl endopeptidase

Cyclooxygenase-2

Conditions:

Hypertriglyceridemia

Major depressive disorder

Alzheimer’s disease

Icosapent is an important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardio...

vascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families. EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.

Doconexent lysine salt

4RSC9PF5VC

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Status:

Possibly Marketed Outside US

First approved in 2007

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

NF-kappa B signaling pathway

Voltage-gated L-type calcium channel

fatty acid metabolic process

Conditions:

Alzheimer’s disease

Coronary heart disease

Age-related macular degeneration

Doconexent (Docosahexaenoic acid, DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. DHA is widely used as a food supplement, and is beleived to support healthy brain developmen...

t in young childred, prevent cardiovascular disease and cognitive decline during Alzheimer's disease. Most of these claims, however, were not supported by clinical trials. DHA spray is used as a tanner.

DOCONEXENT SODIUM

295P7EPT4C

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Status:

Possibly Marketed Outside US

First approved in 2007

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NF-kappa B signaling pathway

Voltage-gated L-type calcium channel

fatty acid metabolic process

Conditions:

Alzheimer’s disease

Coronary heart disease

Age-related macular degeneration

Doconexent (Docosahexaenoic acid, DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. DHA is widely used as a food supplement, and is beleived to support healthy brain developmen...

t in young childred, prevent cardiovascular disease and cognitive decline during Alzheimer's disease. Most of these claims, however, were not supported by clinical trials. DHA spray is used as a tanner.

ETHYL DOCOSAHEXAENOATE

7PO7G8PA8M

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Status:

Possibly Marketed Outside US

First approved in 2007

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NF-kappa B signaling pathway

Voltage-gated L-type calcium channel

fatty acid metabolic process

Conditions:

Alzheimer’s disease

Coronary heart disease

Age-related macular degeneration

Doconexent (Docosahexaenoic acid, DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. DHA is widely used as a food supplement, and is beleived to support healthy brain developmen...

t in young childred, prevent cardiovascular disease and cognitive decline during Alzheimer's disease. Most of these claims, however, were not supported by clinical trials. DHA spray is used as a tanner.

HHS VULNERABILITY DISCLOSURE

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National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966


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