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Showing 1 - 7 of 7 results
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
The cyclopentenone prostaglandin A1 (PGA1) is considered as an antitumor agent. Its action basis on two distinct mechanisms: direct cytostatic/cytotoxic effects on cancer cells. In addition, the second one is the inhibitory activity of a tumor-associated enzymatic function (i.e., telomerase) that is responsible for cancer cell immortality. In addition, was shown, that PGA1 triggers apoptosis by a process that entails the specific activation of H- and N-Ras isoforms, leading to caspase activation. Rodent models with focal cerebral ischemia have shown that PGA1 has the neuroprotective potential.
Status:
US Previously Marketed
First approved in 1945
Class (Stereo):
CHEMICAL (ACHIRAL)
Dichlorophenarsine is a potent anti-syphilitic drug, which exhibits a rapid effect on the serological reactions of the blood in early syphilis. Dichlorophenarsine was more rapid than thiacetarsamide sodium in its action against the canine heartworms infections. Dichlorophenarsine was used for the treatment of canine filariasis - emesia, nausea, and shock occurred several to 30 minutes after injection. Ascorbic acid and hesperidin methyl chalcone when used as a combined therapy afforded a definite protection in mice against the toxic effect of a single dose of intravenously administered dichlorophenarsine hydrochloride.
Status:
US Previously Marketed
First approved in 1945
Class (Stereo):
CHEMICAL (ACHIRAL)
Dichlorophenarsine is a potent anti-syphilitic drug, which exhibits a rapid effect on the serological reactions of the blood in early syphilis. Dichlorophenarsine was more rapid than thiacetarsamide sodium in its action against the canine heartworms infections. Dichlorophenarsine was used for the treatment of canine filariasis - emesia, nausea, and shock occurred several to 30 minutes after injection. Ascorbic acid and hesperidin methyl chalcone when used as a combined therapy afforded a definite protection in mice against the toxic effect of a single dose of intravenously administered dichlorophenarsine hydrochloride.