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Details

Stereochemistry ACHIRAL
Molecular Formula C6H6AsCl2NO.ClH
Molecular Weight 290.406
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DICHLOROPHENARSINE HYDROCHLORIDE

SMILES

Cl.NC1=C(O)C=CC(=C1)[As](Cl)Cl

InChI

InChIKey=LOYXLMNYVHOJJJ-UHFFFAOYSA-N
InChI=1S/C6H6AsCl2NO.ClH/c8-7(9)4-1-2-6(11)5(10)3-4;/h1-3,11H,10H2;1H

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H6AsCl2NO
Molecular Weight 253.946
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Dichlorophenarsine is a potent anti-syphilitic drug, which exhibits a rapid effect on the serological reactions of the blood in early syphilis. Dichlorophenarsine was more rapid than thiacetarsamide sodium in its action against the canine heartworms infections. Dichlorophenarsine was used for the treatment of canine filariasis - emesia, nausea, and shock occurred several to 30 minutes after injection. Ascorbic acid and hesperidin methyl chalcone when used as a combined therapy afforded a definite protection in mice against the toxic effect of a single dose of intravenously administered dichlorophenarsine hydrochloride.

Approval Year

Sample Use Guides

In Vivo Use Guide
0.75mg AS/kg daily for two consecutive days.
Route of Administration: Intravenous
Substance Class Chemical
Record UNII
571850CM3R
Record Status Validated (UNII)
Record Version