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US Approved Rx

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Primary Target

DNA

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tRNA (cytosine(38)-C(5))-methyltransferase

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Highest Phase

Approved

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Approval Year

1984

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Condition

Pneumocystis jiroveci pneumonia (PJP) in high-risk, HIV-infected patients

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Treatment Modality

Preventing

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CNS Activity

CNS Penetrant

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Originator

Ewins, A.J.

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Chemical

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EPA CompTox

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FDA UNII

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PUBCHEM

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DRUG BANK

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ATC Level 1

ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS

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ATC Level 2

ANTIPROTOZOALS

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ATC Level 3

AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS

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ATC Level 4

Other agents against leishmaniasis and trypanosomiasis

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Substance Form

Salts, Hydrates, Esters, etc.

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Showing 1 - 6 of 6 results

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PENTAMIDINE

673LC5J4LQ

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Status:

US Approved Rx (2023)

First approved in 1984

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

tRNA (cytosine(38)-C(5))-methyltransferase

Conditions:

Pneumocystis jiroveci pneumonia (PJP) in high-risk, HIV-infected patients

Pentamidine (formulated as a salt, pentamidine diisethionate or dimesilate) is an antimicrobial medication given for prevention and treatment of pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinii), a...

severe interstitial type of pneumonia often seen in patients with HIV infection. The drug is also the mainstay of treatment for stage I infection with Trypanosoma bruceigambiense (West African trypanosomiasis). Pentamidine is also used as a prophylactic against PCP in patients receiving chemotherapy and in some patients who have undergone organ transplantation, as they also have a depressed immune system as a direct side-effect of the drugs used. The mortality of untreated PCP is very high. Additionally, pentamidine has good clinical activity in treating leishmaniasis, and yeast infections caused by the organism Candida albicans. Pentamidine is also used as a prophylactic antibiotic for children undergoing treatment for leukemia. Studies suggest that the pentamidine isethionate interferes with microbial nuclear metabolism by inhibition of DNA, RNA, phospholipid and protein synthesis. However, the mode of action is not fully understood.

PENTAMIDINE MONOMESYLATE

HMB3ISP7OB

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Status:

US Approved Rx (2023)

First approved in 1984

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

tRNA (cytosine(38)-C(5))-methyltransferase

Conditions:

Pneumocystis jiroveci pneumonia (PJP) in high-risk, HIV-infected patients

Pentamidine (formulated as a salt, pentamidine diisethionate or dimesilate) is an antimicrobial medication given for prevention and treatment of pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinii), a...

severe interstitial type of pneumonia often seen in patients with HIV infection. The drug is also the mainstay of treatment for stage I infection with Trypanosoma bruceigambiense (West African trypanosomiasis). Pentamidine is also used as a prophylactic against PCP in patients receiving chemotherapy and in some patients who have undergone organ transplantation, as they also have a depressed immune system as a direct side-effect of the drugs used. The mortality of untreated PCP is very high. Additionally, pentamidine has good clinical activity in treating leishmaniasis, and yeast infections caused by the organism Candida albicans. Pentamidine is also used as a prophylactic antibiotic for children undergoing treatment for leukemia. Studies suggest that the pentamidine isethionate interferes with microbial nuclear metabolism by inhibition of DNA, RNA, phospholipid and protein synthesis. However, the mode of action is not fully understood.

PENTAMIDINE DIHYDROCHLORIDE

I0I0257YP1

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Status:

US Approved Rx (2023)

First approved in 1984

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

tRNA (cytosine(38)-C(5))-methyltransferase

Conditions:

Pneumocystis jiroveci pneumonia (PJP) in high-risk, HIV-infected patients

Pentamidine (formulated as a salt, pentamidine diisethionate or dimesilate) is an antimicrobial medication given for prevention and treatment of pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinii), a...

severe interstitial type of pneumonia often seen in patients with HIV infection. The drug is also the mainstay of treatment for stage I infection with Trypanosoma bruceigambiense (West African trypanosomiasis). Pentamidine is also used as a prophylactic against PCP in patients receiving chemotherapy and in some patients who have undergone organ transplantation, as they also have a depressed immune system as a direct side-effect of the drugs used. The mortality of untreated PCP is very high. Additionally, pentamidine has good clinical activity in treating leishmaniasis, and yeast infections caused by the organism Candida albicans. Pentamidine is also used as a prophylactic antibiotic for children undergoing treatment for leukemia. Studies suggest that the pentamidine isethionate interferes with microbial nuclear metabolism by inhibition of DNA, RNA, phospholipid and protein synthesis. However, the mode of action is not fully understood.

PENTAMIDINE GLUCONATE

B0WU872RIR

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Status:

US Approved Rx (2023)

First approved in 1984

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

tRNA (cytosine(38)-C(5))-methyltransferase

Conditions:

Pneumocystis jiroveci pneumonia (PJP) in high-risk, HIV-infected patients

Pentamidine (formulated as a salt, pentamidine diisethionate or dimesilate) is an antimicrobial medication given for prevention and treatment of pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinii), a...

severe interstitial type of pneumonia often seen in patients with HIV infection. The drug is also the mainstay of treatment for stage I infection with Trypanosoma bruceigambiense (West African trypanosomiasis). Pentamidine is also used as a prophylactic against PCP in patients receiving chemotherapy and in some patients who have undergone organ transplantation, as they also have a depressed immune system as a direct side-effect of the drugs used. The mortality of untreated PCP is very high. Additionally, pentamidine has good clinical activity in treating leishmaniasis, and yeast infections caused by the organism Candida albicans. Pentamidine is also used as a prophylactic antibiotic for children undergoing treatment for leukemia. Studies suggest that the pentamidine isethionate interferes with microbial nuclear metabolism by inhibition of DNA, RNA, phospholipid and protein synthesis. However, the mode of action is not fully understood.

PENTAMIDINE ISETHIONATE

V2P3K60DA2

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Status:

US Approved Rx (2023)

First approved in 1984

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

tRNA (cytosine(38)-C(5))-methyltransferase

Conditions:

Pneumocystis jiroveci pneumonia (PJP) in high-risk, HIV-infected patients

Pentamidine (formulated as a salt, pentamidine diisethionate or dimesilate) is an antimicrobial medication given for prevention and treatment of pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinii), a...

severe interstitial type of pneumonia often seen in patients with HIV infection. The drug is also the mainstay of treatment for stage I infection with Trypanosoma bruceigambiense (West African trypanosomiasis). Pentamidine is also used as a prophylactic against PCP in patients receiving chemotherapy and in some patients who have undergone organ transplantation, as they also have a depressed immune system as a direct side-effect of the drugs used. The mortality of untreated PCP is very high. Additionally, pentamidine has good clinical activity in treating leishmaniasis, and yeast infections caused by the organism Candida albicans. Pentamidine is also used as a prophylactic antibiotic for children undergoing treatment for leukemia. Studies suggest that the pentamidine isethionate interferes with microbial nuclear metabolism by inhibition of DNA, RNA, phospholipid and protein synthesis. However, the mode of action is not fully understood.

PENTAMIDINE MESYLATE

863QBB4D0A

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Status:

US Approved Rx (2023)

First approved in 1984

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

tRNA (cytosine(38)-C(5))-methyltransferase

Conditions:

Pneumocystis jiroveci pneumonia (PJP) in high-risk, HIV-infected patients

Pentamidine (formulated as a salt, pentamidine diisethionate or dimesilate) is an antimicrobial medication given for prevention and treatment of pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinii), a...

severe interstitial type of pneumonia often seen in patients with HIV infection. The drug is also the mainstay of treatment for stage I infection with Trypanosoma bruceigambiense (West African trypanosomiasis). Pentamidine is also used as a prophylactic against PCP in patients receiving chemotherapy and in some patients who have undergone organ transplantation, as they also have a depressed immune system as a direct side-effect of the drugs used. The mortality of untreated PCP is very high. Additionally, pentamidine has good clinical activity in treating leishmaniasis, and yeast infections caused by the organism Candida albicans. Pentamidine is also used as a prophylactic antibiotic for children undergoing treatment for leukemia. Studies suggest that the pentamidine isethionate interferes with microbial nuclear metabolism by inhibition of DNA, RNA, phospholipid and protein synthesis. However, the mode of action is not fully understood.

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