Inxight Drugs

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Originator

Schneider, J.A. et al.

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Pfizer

420

Eli Lilly

239

Merck

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GlaxoSmithKline

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US Previously Marketed

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Primary Target

Synaptic vesicular amine transporter

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Approved

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Approval Year

1957

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Condition

Hypertension

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Primary

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CNS Active

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ANTIADRENERGIC AGENTS, CENTRALLY ACTING

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ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION

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ATC Level 4

Rauwolfia alkaloids

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Rauwolfia alkaloids and diuretics in combination

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Salts, Hydrates, Esters, etc.

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DESERPIDINE

9016E3VB47

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Status:

US Previously Marketed

First approved in 1957

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Synaptic vesicular amine transporter

Conditions:

Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. Rauwol...

fia alkaloids work by controlling nerve impulses along certain nerve pathways. As a result, they act on the heart and blood vessels to lower blood pressure. Deserpidine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.

DESERPIDINE OXALATE

9X2GS858BC

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Status:

US Previously Marketed

First approved in 1957

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Synaptic vesicular amine transporter

Conditions:

Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. Rauwol...

fia alkaloids work by controlling nerve impulses along certain nerve pathways. As a result, they act on the heart and blood vessels to lower blood pressure. Deserpidine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.

DESERPIDINE HYDROCHLORIDE

6LPC48045D

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Status:

US Previously Marketed

First approved in 1957

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Synaptic vesicular amine transporter

Conditions:

Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. Rauwol...

fia alkaloids work by controlling nerve impulses along certain nerve pathways. As a result, they act on the heart and blood vessels to lower blood pressure. Deserpidine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.

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