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Originator

Fieser, L.F.

4

Pfizer

420

Eli Lilly

239

Merck

238

GlaxoSmithKline

197

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Development Status

US Previously Marketed

4

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Primary Target

Aldose reductase (Gallus gallus)

3

Heme oxygenase 1

3

NQO1 protein

3

Complement and Coagulation Cascades

1

Vitamin digestion and absorption

1

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Highest Phase

Phase III

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Approved

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Approval Year

1940

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Condition

Dicumarol toxicity

3

Organophosphorus pesticides intoxication

3

Vomiting of pregnancy

3

Allergic rhinitis

1

Severe hypoprothrombinaemia

1

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Treatment Modality

Primary

4

Palliative

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CNS Activity

CNS Penetrant

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Substance Class

Chemical

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CAS

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CHEBI

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FDA UNII

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PUBCHEM

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SMS_ID

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ATC Level 1

BLOOD AND BLOOD FORMING ORGANS

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ATC Level 2

ANTIHEMORRHAGICS

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ATC Level 3

VITAMIN K AND OTHER HEMOSTATICS

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ATC Level 4

Vitamin K

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Substance Form

Principal Form

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Salts, Hydrates, Esters, etc.

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MENADIONE BISULFITE

I2BE1ZEN8I

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Status:

US Previously Marketed

First approved in 1940

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Heme oxygenase 1

Aldose reductase (Gallus gallus)

Conditions:

Dicumarol toxicity

Vomiting of pregnancy

Organophosphorus pesticides intoxication

Menadione bisulfite is a water-soluble analog of Vitamin K3. Pharmacologic studies on menadione bisulfate indicad that its toxicity is relatively low. In man, doses approximately ten times as great as those generally recommended for therapeutic use,...

given daily for a period of one week. Redox cycling compounds, such as menadione, have the potential to effectively mitigate the toxicity of organophosphorus pesticides including parathion. Menadione bisulfite behaved as a competitive inhibitor of chicken muscle aldose reductase.

MENADIONE

723JX6CXY5

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Status:

US Previously Marketed

First approved in 1940

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Vitamin digestion and absorption

Complement and Coagulation Cascades

Conditions:

Vitamin K deficiency

Severe hypoprothrombinaemia

Allergic rhinitis

Menadione, a drug belong to class of Vitamin K, is prescribed for the treatment of hemorrhage, vitamin K deficiency, moderate to severe forms of hypoprothrombinaemia in adults and children. Menadione is a synthetic form of vitamin K, a lipid-soluble ...

vitamin. Vitamin K is a vital cofactor for the biosynthesis of prothrombin, factor VII, IX, X, protein C and protein S. Menadione supports the functions of osteocalcin. Large doses of menadione have been reported to cause adverse outcomes including hemolytic anemia due to glucose-6-phosphate dehydrogenase deficiency, neonatal brain or liver damage, or neonatal death in some rare cases.

MENADIONE SODIUM BISULFITE ANHYDROUS

97K34V88SA

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Status:

US Previously Marketed

First approved in 1940

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Heme oxygenase 1

Aldose reductase (Gallus gallus)

Conditions:

Dicumarol toxicity

Vomiting of pregnancy

Organophosphorus pesticides intoxication

Menadione bisulfite is a water-soluble analog of Vitamin K3. Pharmacologic studies on menadione bisulfate indicad that its toxicity is relatively low. In man, doses approximately ten times as great as those generally recommended for therapeutic use,...

given daily for a period of one week. Redox cycling compounds, such as menadione, have the potential to effectively mitigate the toxicity of organophosphorus pesticides including parathion. Menadione bisulfite behaved as a competitive inhibitor of chicken muscle aldose reductase.

MENADIONE SODIUM BISULFITE

6XF3C2HK77

Export Data
Search for Structure

Status:

US Previously Marketed

First approved in 1940

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Heme oxygenase 1

Aldose reductase (Gallus gallus)

Conditions:

Dicumarol toxicity

Vomiting of pregnancy

Organophosphorus pesticides intoxication

Menadione bisulfite is a water-soluble analog of Vitamin K3. Pharmacologic studies on menadione bisulfate indicad that its toxicity is relatively low. In man, doses approximately ten times as great as those generally recommended for therapeutic use,...

given daily for a period of one week. Redox cycling compounds, such as menadione, have the potential to effectively mitigate the toxicity of organophosphorus pesticides including parathion. Menadione bisulfite behaved as a competitive inhibitor of chicken muscle aldose reductase.

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