Details
Stereochemistry | RACEMIC |
Molecular Formula | C11H9O5S.Na.3H2O |
Molecular Weight | 330.287 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.O.[Na+].CC1(CC(=O)C2=CC=CC=C2C1=O)S([O-])(=O)=O
InChI
InChIKey=SRPZAZGARCFWTO-UHFFFAOYSA-M
InChI=1S/C11H10O5S.Na.3H2O/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;;;;/h2-5H,6H2,1H3,(H,14,15,16);;3*1H2/q;+1;;;/p-1
Molecular Formula | H2O |
Molecular Weight | 18.0153 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C11H10O5S |
Molecular Weight | 254.259 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/14952541Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/3927923 | https://www.ncbi.nlm.nih.gov/pubmed/18935165 | https://www.ncbi.nlm.nih.gov/pubmed/26212258
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14952541
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/3927923 | https://www.ncbi.nlm.nih.gov/pubmed/18935165 | https://www.ncbi.nlm.nih.gov/pubmed/26212258
Menadione bisulfite is a water-soluble analog of Vitamin K3. Pharmacologic studies on menadione bisulfate indicad that its toxicity is relatively low. In man, doses approximately ten times as great as those generally recommended for therapeutic use, given daily for a period of one week. Redox cycling compounds, such as menadione, have the potential to effectively mitigate the toxicity of organophosphorus pesticides including parathion. Menadione bisulfite behaved as a competitive inhibitor of chicken muscle aldose reductase.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL5035 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11081416 |
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Target ID: CHEMBL2169730 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9324955 |
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Target ID: Aldose reductase (Gallus gallus) Sources: https://www.ncbi.nlm.nih.gov/pubmed/3927923 |
0.025 mM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
Doses
Dose | Population | Adverse events |
---|---|---|
10 mg 10 times / day multiple, oral Highest studied dose Dose: 10 mg, 10 times / day Route: oral Route: multiple Dose: 10 mg, 10 times / day Co-administed with:: Vitamin C, p.o(500 mg; 10 times/day) Sources: Page: p.64 |
unhealthy, 56 – 85 n = 3 Health Status: unhealthy Condition: Prostate cancer Age Group: 56 – 85 Sex: M Population Size: 3 Sources: Page: p.64 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14952541
5 mg. Therapy, averaging thirty days, was continued until the withdrawal of metlication produced no recurrence of symptoms.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2250668
Addition of menadione bisulfite (3 mM) alone to the perfusate increased oxygen uptake by 20-30 uM/g/hr. In the presence of ethanol, maximal increases in oxygen uptake due to menadione bisulfite were much larger (about 90 uM/g/hr), and lactate dehydrogenase release occurred earlier and reached higher maximal values (330 units/g/hr).
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 16 16:37:27 UTC 2022
by
admin
on
Fri Dec 16 16:37:27 UTC 2022
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Record UNII |
6XF3C2HK77
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Record Status |
Validated (UNII)
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Record Version |
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-
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Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
392513
Created by
admin on Fri Dec 16 16:37:28 UTC 2022 , Edited by admin on Fri Dec 16 16:37:28 UTC 2022
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EU-Orphan Drug |
EU/3/14/1308
Created by
admin on Fri Dec 16 16:37:28 UTC 2022 , Edited by admin on Fri Dec 16 16:37:28 UTC 2022
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FDA ORPHAN DRUG |
395413
Created by
admin on Fri Dec 16 16:37:28 UTC 2022 , Edited by admin on Fri Dec 16 16:37:28 UTC 2022
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FDA ORPHAN DRUG |
394313
Created by
admin on Fri Dec 16 16:37:28 UTC 2022 , Edited by admin on Fri Dec 16 16:37:28 UTC 2022
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NCI_THESAURUS |
C26017
Created by
admin on Fri Dec 16 16:37:28 UTC 2022 , Edited by admin on Fri Dec 16 16:37:28 UTC 2022
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FDA ORPHAN DRUG |
236606
Created by
admin on Fri Dec 16 16:37:28 UTC 2022 , Edited by admin on Fri Dec 16 16:37:28 UTC 2022
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FDA ORPHAN DRUG |
429014
Created by
admin on Fri Dec 16 16:37:28 UTC 2022 , Edited by admin on Fri Dec 16 16:37:28 UTC 2022
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FDA ORPHAN DRUG |
430114
Created by
admin on Fri Dec 16 16:37:28 UTC 2022 , Edited by admin on Fri Dec 16 16:37:28 UTC 2022
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Code System | Code | Type | Description | ||
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6XF3C2HK77
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6147-37-1
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DTXSID10977032
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admin on Fri Dec 16 16:37:28 UTC 2022 , Edited by admin on Fri Dec 16 16:37:28 UTC 2022
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M7169
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1684
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23677974
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C83928
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52551
Created by
admin on Fri Dec 16 16:37:28 UTC 2022 , Edited by admin on Fri Dec 16 16:37:28 UTC 2022
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PRIMARY | RxNorm | ||
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63928
Created by
admin on Fri Dec 16 16:37:28 UTC 2022 , Edited by admin on Fri Dec 16 16:37:28 UTC 2022
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CHEMBL1159684
Created by
admin on Fri Dec 16 16:37:28 UTC 2022 , Edited by admin on Fri Dec 16 16:37:28 UTC 2022
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PRIMARY |
Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE | |||
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ANHYDROUS->SOLVATE |