Details
Stereochemistry | RACEMIC |
Molecular Formula | C11H10O5S |
Molecular Weight | 254.259 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(CC(=O)C2=CC=CC=C2C1=O)S(O)(=O)=O
InChI
InChIKey=WIXFIQKTHUVFDI-UHFFFAOYSA-N
InChI=1S/C11H10O5S/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13/h2-5H,6H2,1H3,(H,14,15,16)
Molecular Formula | C11H10O5S |
Molecular Weight | 254.259 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/14952541Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/3927923 | https://www.ncbi.nlm.nih.gov/pubmed/18935165 | https://www.ncbi.nlm.nih.gov/pubmed/26212258
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14952541
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/3927923 | https://www.ncbi.nlm.nih.gov/pubmed/18935165 | https://www.ncbi.nlm.nih.gov/pubmed/26212258
Menadione bisulfite is a water-soluble analog of Vitamin K3. Pharmacologic studies on menadione bisulfate indicad that its toxicity is relatively low. In man, doses approximately ten times as great as those generally recommended for therapeutic use, given daily for a period of one week. Redox cycling compounds, such as menadione, have the potential to effectively mitigate the toxicity of organophosphorus pesticides including parathion. Menadione bisulfite behaved as a competitive inhibitor of chicken muscle aldose reductase.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL5035 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11081416 |
|||
Target ID: CHEMBL2169730 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9324955 |
|||
Target ID: Aldose reductase (Gallus gallus) Sources: https://www.ncbi.nlm.nih.gov/pubmed/3927923 |
0.025 mM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14952541
5 mg. Therapy, averaging thirty days, was continued until the withdrawal of metlication produced no recurrence of symptoms.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2250668
Addition of menadione bisulfite (3 mM) alone to the perfusate increased oxygen uptake by 20-30 uM/g/hr. In the presence of ethanol, maximal increases in oxygen uptake due to menadione bisulfite were much larger (about 90 uM/g/hr), and lactate dehydrogenase release occurred earlier and reached higher maximal values (330 units/g/hr).
Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:13:40 GMT 2025
by
admin
on
Mon Mar 31 18:13:40 GMT 2025
|
Record UNII |
I2BE1ZEN8I
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
I2BE1ZEN8I
Created by
admin on Mon Mar 31 18:13:40 GMT 2025 , Edited by admin on Mon Mar 31 18:13:40 GMT 2025
|
PRIMARY | |||
|
63930
Created by
admin on Mon Mar 31 18:13:40 GMT 2025 , Edited by admin on Mon Mar 31 18:13:40 GMT 2025
|
PRIMARY | |||
|
8536
Created by
admin on Mon Mar 31 18:13:40 GMT 2025 , Edited by admin on Mon Mar 31 18:13:40 GMT 2025
|
PRIMARY | |||
|
300000029211
Created by
admin on Mon Mar 31 18:13:40 GMT 2025 , Edited by admin on Mon Mar 31 18:13:40 GMT 2025
|
PRIMARY | |||
|
130-36-9
Created by
admin on Mon Mar 31 18:13:40 GMT 2025 , Edited by admin on Mon Mar 31 18:13:40 GMT 2025
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
SALT/SOLVATE -> PARENT | |||
|
SALT/SOLVATE -> PARENT |