Ciclopramine is a tetracyclic antidepressant patented by the pharmaceutical company “Chemische Fabrik Promonta G.m.b.H.” for central nervous system disorders treatment.

Prodipine (also known as BY-101) is diphenylpiperidines derivative patented by Chemische Fabrik Promonta G.m.b.H. as an anti parkinsonian agent. Prodipine showed monoamine oxidase inhibiting effects in vitro (liver and brain homogenates) similar to those of harmaline. In preclinical studies, Prodipine caused no tachyphylaxis, no increased salivation, or hyperthermia, and had lower toxicity in mice than amphetamine or pemoline. Prodipine decreased reserpine-induced ptosis, antagonized tremorine-induced seizures, and caused only mild hypertension in mice.

Prodipine (also known as BY-101) is diphenylpiperidines derivative patented by Chemische Fabrik Promonta G.m.b.H. as an anti parkinsonian agent. Prodipine showed monoamine oxidase inhibiting effects in vitro (liver and brain homogenates) similar to those of harmaline. In preclinical studies, Prodipine caused no tachyphylaxis, no increased salivation, or hyperthermia, and had lower toxicity in mice than amphetamine or pemoline. Prodipine decreased reserpine-induced ptosis, antagonized tremorine-induced seizures, and caused only mild hypertension in mice.