U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 451 - 460 of 511 results

Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(7) dandruff lauryl isoquinolinium bromide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Lauryl isoquinolium bromide is one of the active components of Decelerine a cosmetic product which is used for its soothing, moisturizing and regenerating effects on the skin.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(6)(i) cough/cold:antihistamine thenyldiamine hydrochloride
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


There is not much available information about thenyldiamine, is known, that it is used as antihistamine and for the treatment of asthma and bronchitis.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(6)(i) cough/cold:antihistamine thenyldiamine hydrochloride
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


There is not much available information about thenyldiamine, is known, that it is used as antihistamine and for the treatment of asthma and bronchitis.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(7) dandruff lauryl isoquinolinium bromide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Lauryl isoquinolium bromide is one of the active components of Decelerine a cosmetic product which is used for its soothing, moisturizing and regenerating effects on the skin.
Nigericin is an antibiotic derived from Streptomyces “Nig-1”. It is the potassium ionophore and H+/K+ exchanger. It is shown to be highly effective as an ionophore for Pb(2+). Thus, nigericin may be more useful than monensin in the treatment of Pb intoxication. Nigericin induced mitochondrial membrane hyperpolarization. Malignant characteristics of human glioma cells were markedly suppressed by nigericin treatment in vivo. Nigericin induces cell death and promotes the maturation and release of IL-1beta in lipopolysaccharide (LPS)-primed monocytes and macrophages. The mechanism of induction of apoptosis by nigericin is most probably to decrease intracellular pH.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

N-palmitoyl glycine, an endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. N-palmitoyl glycine is used in cosmetic under the brand name TIMECODE™ for deep wrinkles and helps relieve chronic silent inflammation, increases micro-circulation due to poor oxygenation and lack of nutrients. This product is also recommended for sensitive skin and for tired skin.
Status:
Possibly Marketed Outside US
Source:
Canada:ARSONOACETIC ACID,DISODIUM SALT
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Disodiurn salt of Arsonoacetic acid has been used in veterinary to treat anaplasmosis (babesiasis); as general stimulant in nervous disease; for eclampsia of bitches, and with adjuncts in chronic eczema and follicular mange. Arsonoacetic acid has not featured much in human medicine, a Chinese patent however, was filed in 2003 for arsonoacetic acid and its methyl or ethyl derivatives as chemotherapeutic drugs again liver cancer.
Status:
Possibly Marketed Outside US
Source:
Canada:ARSONOACETIC ACID,DISODIUM SALT
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Disodiurn salt of Arsonoacetic acid has been used in veterinary to treat anaplasmosis (babesiasis); as general stimulant in nervous disease; for eclampsia of bitches, and with adjuncts in chronic eczema and follicular mange. Arsonoacetic acid has not featured much in human medicine, a Chinese patent however, was filed in 2003 for arsonoacetic acid and its methyl or ethyl derivatives as chemotherapeutic drugs again liver cancer.
Status:
Possibly Marketed Outside US
Source:
NuFera by CarWin Pharmaceutical Associates, LLC
(2015)
Source URL:
First approved in 2015
Source:
NuFera by CarWin Pharmaceutical Associates, LLC
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Keracyanin (antirrhinin) is the pigment originally isolated from the fruit of the cherry. The compound exerts potent antioxidant properties. It is able to inhibit host- and bacteria-derived proteinases. Dietary supplementation with purified keracyanin suppresses body weight gain in high-fat diet fed mice.
Status:
Possibly Marketed Outside US
Source:
NCT00955955: Phase 4 Interventional Completed Depression
(2009)
Source URL:
First approved in 2012

Class (Stereo):
CHEMICAL (EPIMERIC)



Methylenetetrahydrofolate reductase (MTHFR) is an enzyme required for the formation of 5-methyltetrahydrofolate (5-MTHF), a form of folate able to cross the blood-brain barrier and which is necessary as a substrate for the remethylation of homocysteine to methionine by methionine synthase. Patients with severe MTHFR deficiency cannot make 5-MTHF and have extremely low levels in the CSF. Only treatment with oral 5-MTHF given as calcium mefolinate resulted in an increase in CSF 5-MTHF.

Showing 451 - 460 of 511 results