DISODIUM ARSONOACETATE MONOHYDRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H3AsO5.2Na.H2O
Molecular Weight	245.9586
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DISODIUM ARSONOACETATE MONOHYDRATE

Structure Search

SMILES

O.[Na+].[Na+].O[As]([O-])(=O)CC([O-])=O

InChI

InChIKey=RJTDUAJFVQDGBM-UHFFFAOYSA-L

InChI=1S/C2H5AsO5.2Na.H2O/c4-2(5)1-3(6,7)8;;;/h1H2,(H,4,5)(H2,6,7,8);;;1H2/q;2*+1;/p-2

HIDE SMILES / InChI

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/67177Sullivan, R.J. (1969) 'AIR POLLUTION ASPECTS OF ARSENIC AND ITS COMPOUNDS', p.60 Retrieved from https://yosemite.epa.gov/oa/EAB_Web_Docket.nsf/Attachments%20By%20ParentFilingId/3B14C316D06D4BCE85257F40006A588B//NAPCA%201969.pdf
Curator's Comment: description was created based on several sources, including: Wilson, P.S. (2009) "Rediscovering Arsenoacetic Acid", p.9 Retrieved from http://researchcommons.waikato.ac.nz/bitstream/handle/10289/2778/thesis.pdf?sequence=1

Disodiurn salt of Arsonoacetic acid has been used in veterinary to treat anaplasmosis (babesiasis); as general stimulant in nervous disease; for eclampsia of bitches, and with adjuncts in chronic eczema and follicular mange. Arsonoacetic acid has not featured much in human medicine, a Chinese patent however, was filed in 2003 for arsonoacetic acid and its methyl or ethyl derivatives as chemotherapeutic drugs again liver cancer.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial DNA-directed RNA polymerase 11 Target ID: CHEMBL2364672 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6083781	Modulator 846

Conditions

Condition	Modality	Highest Phase	Product
Babesiosis 7 Sources: Sullivan, R.J. (1969) Air pollution aspects of arsenic and its compounds, p.60, retrieved from: https://books.google.ru/books?id=jbcvAAAAYAAJ	Primary	Not Provided 511	Unknown Approved Use Unknown
Nervous diseases 3 Sources: Sullivan, R.J. (1969) Air pollution aspects of arsenic and its compounds, p.60, retrieved from: https://books.google.ru/books?id=jbcvAAAAYAAJ	Primary	Not Provided 511	Unknown Approved Use Unknown
Eclampsia 69 Sources: Sullivan, R.J. (1969) Air pollution aspects of arsenic and its compounds, p.60, retrieved from: https://books.google.ru/books?id=jbcvAAAAYAAJ	Primary	Not Provided 511	Unknown Approved Use Unknown
Nutritional supplements 3 Sources: http://starlabs.com.pk/mericyl-injection.html	Primary	Not Provided 511	MERICYL Approved Use Roborant and general tonic (nutritional supplements)
Dental cavities 3 Sources: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=35df5050-2215-4b1d-e054-00144ff8d46c&type=display	Inactive ingredient	Not Provided 511	AMERFRESH Approved Use Aids in the prevention of dental cavities

PubMed

Title	Date	PubMed
Tumor cell-specific prodrugs using arsonic acid-presenting iron oxide nanoparticles with high sensitivity.	2012-08-01	22743089
Arsonic acid-presenting superparamagnetic iron oxide for pH-responsive aggregation under slightly acidic conditions.	2011-04-01	21393003
The construction of a whole-cell biosensor for phosphonoacetate, based on the LysR-like transcriptional regulator PhnR from Pseudomonas fluorescens 23F.	2009-03	21261917
Carbon-arsenic bond cleavage by a newly isolated gram-negative bacterium, strain ASV2.	1995-03	7711909
The mechanism of pyrophosphorolysis of RNA by RNA polymerase. Endowment of RNA polymerase with artificial exonuclease activity.	1984-12-01	6083781
Mode of action of phosphonoformate as an anti-herpes simplex virus agent.	1981-01-29	6260189

Patents

Sample Use Guides

In Vivo Use Guide

Horses, Cattle 10 ml Sheep, Goats 2-5 ml Big dogs 1.2 ml Dogs, Cats 0.2-0.5 ml Each ml contains 50 mg of disodium arsonoacetate.

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

ARSONOACETIC ACID SODIUM SALT MONOHYDRATE

Preferred Name

English

DISODIUM ARSONOACETATE MONOHYDRATE

Systematic Name

English

ACETIC ACID, 2-ARSONO-, SODIUM SALT, HYDRATE (1:2:1)

Common Name

English

ARICYL

Brand Name

English

ARSONOACETIC ACID SODIUM SALT MONOHYDRATE [MI]

Common Name

English

ARSONOACETIC ACID DISODIUM SALT MONOHYDRATE

Common Name

English

DISODIUM ACETARSENATE MONOHYDRATE

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID40208922